sameAs
Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage.Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.Human DNA polymerase η accommodates RNA for strand extension.Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol.Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.Introduction to Metals in Biology 2017: Iron transport, storage, and the ramifications.Formation of S-[2-(N6-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases.Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug Metabolizing Enzymes as a Response to Redox Alteration.Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51Formation and Cleavage of C–C Bonds by Enzymatic Oxidation–Reduction ReactionsMitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse modelsCytochrome P450 research and The Journal of Biological ChemistrySterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and CrystallogrA Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic ApproachThe Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid ProductionImpact of 1,N6-ethenoadenosine, a damaged ribonucleotide in DNA, on translesion synthesis and repairMultistep Binding of the Non-Steroidal Inhibitors Orteronel and Seviteronel to Human Cytochrome P450 17A1 and Relevance to Inhibition of Enzyme ActivityIn Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related CompoundsThe safety evaluation of food flavouring substances: the role of metabolic studiesValidation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible InhibitorsGlutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1Celebrating the scientific legacy of Herbert TaborEngineering cytochrome P450 enzyme systems for biomedical and biotechnological applicationsHuman cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosteroneConformational selection dominates binding of steroids to human cytochrome P450 17A1Preference for O-demethylation reactions in the oxidation of 2´-, 3´-, and 4´-methoxyflavones by human cytochrome P450 enzymesThe abundant DNA adduct N 7-methyl deoxyguanosine contributes to miscoding during replication by human DNA polymerase ηHuman DNA polymerase η has reverse transcriptase activity in cellular environmentsIsotopic tagging of oxidized and reduced cysteines (iTORC) for detecting and quantifying sulfenic acids, disulfides, and free thiols in cellsHuman cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modesKinetic Modeling of Steady-State Situations in Cytochrome P450 Enzyme ReactionsOxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 EnzymesDrug Metabolism and Toxicology Special Issue Call for PapersSterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan TrypanosomatidaeA requirement for an active proton delivery network supports a Compound I mediated C-C bond cleavage in CYP51 catalysisIntroduction: Drug Metabolism and Toxicology Special Issue
P50
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