Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent.
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Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic SteatohepatitisMechanism of the promotion of steatotic HepG2 cell apoptosis by cholesterolP2X7 receptor as a key player in oxidative stress-driven cell fate in nonalcoholic steatohepatitis.Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease.Ezetimibe for the treatment of non-alcoholic fatty liver disease: A meta-analysis.Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease.Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress.Immunoregulation by lipids during the development of non-alcoholic steatohepatitis.Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway.Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment.HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease.Splenectomy enhances the therapeutic effect of adipose tissue-derived mesenchymal stem cell infusion on cirrhosis rats.Mitochondrial Cholesterol and the Paradox in Cell Death.A longitudinal study of whole body, tissue, and cellular physiology in a mouse model of fibrosing NASH with high fidelity to the human condition.Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition.Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis.Hepatic leukocyte immunoglobulin-like receptor B4 (LILRB4) attenuates nonalcoholic fatty liver disease via SHP1-TRAF6 pathway.Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.Causes and mechanisms of adipocyte enlargement and adipose expansion.Endoplasmic reticulum stress stimulates the release of extracellular vesicles carrying danger-associated molecular pattern (DAMP) molecules.Prolonged feeding with green tea polyphenols exacerbates cholesterol-induced fatty liver disease in mice.The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice.To die or not to die: death signaling in nonalcoholic fatty liver disease.Plin4-Dependent Lipid Droplets Hamper Neuronal Mitophagy in the MPTP/p-Induced Mouse Model of Parkinson's Disease.Apoptosis and non-alcoholic fatty liver diseases.New Aspects of Lipotoxicity in Nonalcoholic SteatohepatitisDietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signalingHigh-Mobility Group Box-1 and Liver Disease
P2860
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P2860
Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh-hant
name
Hepatocyte free cholesterol li ...... d is HMGB1 and TLR4-dependent.
@en
Hepatocyte free cholesterol li ...... d is HMGB1 and TLR4-dependent.
@nl
type
label
Hepatocyte free cholesterol li ...... d is HMGB1 and TLR4-dependent.
@en
Hepatocyte free cholesterol li ...... d is HMGB1 and TLR4-dependent.
@nl
prefLabel
Hepatocyte free cholesterol li ...... d is HMGB1 and TLR4-dependent.
@en
Hepatocyte free cholesterol li ...... d is HMGB1 and TLR4-dependent.
@nl
P2093
P1476
Hepatocyte free cholesterol li ...... d is HMGB1 and TLR4-dependent.
@en
P2093
Derrick M Van Rooyen
Geoffrey C Farrell
Mark E Koina
Narcissus C Teoh
Robert S McCuskey
P304
P356
10.1016/J.JHEP.2014.07.024
P577
2014-07-24T00:00:00Z