about
Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics.Modulating gradients in regulatory signals within mesenchymal stem cell seeded hydrogels: a novel strategy to engineer zonal articular cartilage.Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem CellsThe Effect of Gradations in Mineral Content, Matrix Alignment, and Applied Strain on Human Mesenchymal Stem Cell Morphology within Collagen Biomaterials.Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity.Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration.Highlight on the dynamic organization of the nucleus.Dynamic regulation of nuclear architecture and mechanics-a rheostatic role for the nucleus in tailoring cellular mechanosensitivity.Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria.Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation.European Society of Biomechanics S.M. Perren Award 2012: the external mechanical environment can override the influence of local substrate in determining stem cell fate.Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria.Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells.Engineering zonal cartilaginous tissue by modulating oxygen levels and mechanical cues through the depth of infrapatellar fat pad stem cell laden hydrogels.The effects of dynamic compression on the development of cartilage grafts engineered using bone marrow and infrapatellar fat pad derived stem cells.Temporal and spatial changes in cartilage-matrix-specific gene expression in mesenchymal stem cells in response to dynamic compression.The Response of Bone Marrow-Derived Mesenchymal Stem Cells to Dynamic Compression Following TGF-β3 Induced Chondrogenic DifferentiationThe effect of concentration, thermal history and cell seeding density on the initial mechanical properties of agarose hydrogelsTamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survivalGPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironmentFunctional properties of cartilaginous tissues engineered from infrapatellar fat pad-derived mesenchymal stem cellsEngineering of large cartilaginous tissues through the use of microchanneled hydrogels and rotational cultureCell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressureLow oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compressionChondrogenesis and integration of mesenchymal stem cells within an in vitro cartilage defect repair modelComposition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat padThe application of plastic compression to modulate fibrin hydrogel mechanical propertiesRetinoic Acid Receptor-β Is Downregulated in Hepatocellular Carcinoma and Cirrhosis and Its Expression Inhibits Myosin-Driven Activation and Durotaxis in Hepatic Stellate CellsTamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptorSyndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathwayAn in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilationGPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Stephen D Thorpe
@nl
Stephen D Thorpe
@sl
Stephen D. Thorpe
@en
Stephen D. Thorpe
@es
type
label
Stephen D Thorpe
@nl
Stephen D Thorpe
@sl
Stephen D. Thorpe
@en
Stephen D. Thorpe
@es
prefLabel
Stephen D Thorpe
@nl
Stephen D Thorpe
@sl
Stephen D. Thorpe
@en
Stephen D. Thorpe
@es
P106
P1153
25636557000
P21
P31
P496
0000-0002-4707-7756