Molecular cloning of resistance genes and architecture of a linked gene cluster involved in biosynthesis of oxytetracycline by Streptomyces rimosus.
about
Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistanceCloning of the complete biosynthetic gene cluster for an aminonucleoside antibiotic, puromycin, and its regulated expression in heterologous hosts.Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.Tetracycline resistance and presence of tetracycline resistance determinants tet(V) and tap in rapidly growing mycobacteria from agricultural soils and clinical isolates.Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C.Oxytetracycline biosynthesis.Streptomyces genetics: a genomic perspective.Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus.Tetracycline resistance determinants in Mycobacterium and Streptomyces species.Antibiotic preparations contain DNA: a source of drug resistance genes?Efflux-mediated antimicrobial resistance.Genetics of Streptomyces rimosus, the oxytetracycline producer.New perspectives in tetracycline resistance.Phosphate control of oxytetracycline production by Streptomyces rimosus is at the level of transcription from promoters overlapped by tandem repeats similar to those of the DNA-binding sites of the OmpR family.Genetic instability and strain degeneration in Streptomyces rimosus.The unstable tetracycline resistance gene of Streptomyces lividans 1326 encodes a putative protein with similarities to translational elongation factors and Tet(M) and Tet(O) proteins.Engineering antibiotic producers to overcome the limitations of classical strain improvement programs.The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants.Revised sequence of OtrB (tet347) tetracycline efflux protein from Streptomyces rimosus.Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.Novobiocin-resistance sequences from the novobiocin-producing strain Streptomyces niveus.Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.Characterization of an oxytetracycline-resistance gene, otrA, of Streptomyces rimosus.
P2860
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P2860
Molecular cloning of resistance genes and architecture of a linked gene cluster involved in biosynthesis of oxytetracycline by Streptomyces rimosus.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
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1989年學術文章
@zh-hant
name
Molecular cloning of resistanc ...... cline by Streptomyces rimosus.
@en
Molecular cloning of resistanc ...... cline by Streptomyces rimosus.
@nl
type
label
Molecular cloning of resistanc ...... cline by Streptomyces rimosus.
@en
Molecular cloning of resistanc ...... cline by Streptomyces rimosus.
@nl
prefLabel
Molecular cloning of resistanc ...... cline by Streptomyces rimosus.
@en
Molecular cloning of resistanc ...... cline by Streptomyces rimosus.
@nl
P2093
P356
P1476
Molecular cloning of resistanc ...... cline by Streptomyces rimosus.
@en
P2093
D A Sugden
E J Friend
F S Kaczmarek
I S Hunter
M J Butler
P2888
P304
P356
10.1007/BF00339722
P577
1989-01-01T00:00:00Z