Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling.
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Cyclic nucleotide signalling in kidney fibrosis.The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitusEarly Observations on the Use of Riociguat in a Large, Metropolitan Pulmonary Arterial Hypertension/Chronic Thromboembolic Pulmonary Hypertension Treatment Center.The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate.Involvement of Cyclic Guanosine Monophosphate-Dependent Protein Kinase I in Renal Antifibrotic Effects of SerelaxinAcetyl-11-Keto-β-Boswellic Acid Attenuates Prooxidant and Profibrotic Mechanisms Involving Transforming Growth Factor-β1, and Improves Vascular Remodeling in Spontaneously Hypertensive Rats.Inhibition of the TGFβ signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis.Systemic sclerosis and localized scleroderma--current concepts and novel targets for therapy.Molecular Physiology of Membrane Guanylyl Cyclase Receptors.Soluble Guanylate Cyclase Stimulators and Activators: Novel Therapies for Pulmonary Vascular Disease or a Different Method of Increasing cGMP?Review: Frontiers of Antifibrotic Therapy in Systemic Sclerosis.Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis.Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies.Cinaciguat ameliorates glomerular damage by reducing ERK1/2 activity and TGF-ß expression in type-1 diabetic ratsDiscovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans.The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis.Stimulators and activators of soluble guanylate cyclase for urogenital disorders.Replacing a phosphodiesterase-5 inhibitor with riociguat in patients with connective tissue disease-associated pulmonary arterial hypertension: a case series.Use of biologics and other novel therapies for the treatment of systemic sclerosis.Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts.Effect of different drug classes on reverse remodeling of intramural coronary arterioles in the spontaneously hypertensive rat.Activating transcription factor 3 regulates canonical TGFβ signalling in systemic sclerosis.Abrogation of transforming growth factor-β-induced tissue fibrosis in TBRIcaCol1a2Cre transgenic mice by the second generation tyrosine kinase inhibitor SKI-606 (Bosutinib).
P2860
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P2860
Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
@zh-hans
2014年学术文章
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2014年学术文章
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2014年學術文章
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2014年學術文章
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name
Stimulation of the soluble gua ...... non-canonical TGFβ signalling.
@en
Stimulation of the soluble guanylate cyclase
@nl
type
label
Stimulation of the soluble gua ...... non-canonical TGFβ signalling.
@en
Stimulation of the soluble guanylate cyclase
@nl
prefLabel
Stimulation of the soluble gua ...... non-canonical TGFβ signalling.
@en
Stimulation of the soluble guanylate cyclase
@nl
P2093
P2860
P1476
Stimulation of the soluble gua ...... non-canonical TGFβ signalling.
@en
P2093
Alfiya Distler
Andreas Friebe
Christian Beyer
Christiane Maier
Christoph Zenzmaier
Clara Dees
Jingang Huang
Jörg H W Distler
Katrin Palumbo-Zerr
Milena L Pachowsky
P2860
P304
P356
10.1136/ANNRHEUMDIS-2013-204508
P407
P50
P577
2014-02-23T00:00:00Z