Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib. - Wikidata - wikimedia - TriplyDB

Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib.

Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib.

http://www.wikidata.org/entity/Q54618750

about

New Insight into the Anti-liver Fibrosis Effect of Multitargeted Tyrosine Kinase Inhibitors: From Molecular Target to Clinical Trials Multimechanistic antifibrotic effect of biochanin a in rats: implications of proinflammatory and profibrogenic mediators Current status of novel antifibrotic therapies in patients with chronic liver disease Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis Targeting the PDGF signaling pathway in the treatment of non-malignant diseases.Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis.Potent effects of dioscin against liver fibrosis.Inhibitory effects of dimethyl α-ketoglutarate in hepatic stellate cell activation Nilotinib protects the murine liver from ischemia/reperfusion injury.Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model.Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis 3,3'-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression.Reversal of hepatic fibrosis: pathophysiological basis of antifibrotic therapies.Different anti-remodeling effect of nilotinib and fluticasone in a chronic asthma model.Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats.Babao Dan attenuates hepatic fibrosis by inhibiting hepatic stellate cells activation and proliferation via TLR4 signaling pathway.Anti-fibrogenic strategies and the regression of fibrosis.Review article: the reversibility of cirrhosis.Review article: The prevention and reversal of hepatic fibrosis in autoimmune hepatitis.Hedgehog signaling pathway as key player in liver fibrosis: new insights and perspectives.Novel insights into TRPM7 function in fibrotic diseases: a potential therapeutic target.Identification of two candidate innate immune genes by transcriptional profiling and RNA interference in mouse mammary gland epithelial cells stimulated with lipopolysaccharide.Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.Phenylethanol Glycosides from Cistanche tubulosa Suppress Hepatic Stellate Cell Activation and Block the Conduction of Signaling Pathways in TGF-β1/smad as Potential Anti-Hepatic Fibrosis Agents.Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells.Targeting Hepatic Fibrosis in Autoimmune Hepatitis.Polyphenols with anti-proliferative activities from Penthorum chinense Pursh.Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways.Modulation of d-galactosamine/lipopolysacharride-induced fulminant hepatic failure by nilotinib.Nilotinib attenuates endothelial dysfunction and liver damage in high-cholesterol-fed rabbits.Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases.A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling.Depletion of β-arrestin2 in hepatic stellate cells reduces cell proliferation via ERK pathway.Hepatic stellate cells as key target in liver fibrosis.Potent inhibition of TGF-β signaling pathway regulator Abl: potential therapeutics for hepatic fibrosis.Ameliorative Effects of Nilotinib on CCl4 Induced Liver Fibrosis Via Attenuation of RAGE/HMGB1 Gene Expression and Oxidative Stress in Rat.Cell-Based Therapies for Tissue Fibrosis.Attenuation of fibrosis with selective inhibition of c-Abl by siRNA in systemic sclerosis dermal fibroblasts.

P2860

Q26772800-2BA6C11F-9393-47DA-8897-4C1EEBEDF3EE Q28534674-903418AE-7603-4EBA-A30E-EFFF86D9EE74 Q30473375-847B18D2-4BE2-4631-ADAA-633515FF1F66 Q31126487-BCA26B85-653E-43F7-ACB9-60CE970F9D8D Q34352802-7BBCF386-196E-4589-9CFE-9E238022DB29 Q34479065-2EFC4CBE-F86D-473C-A635-BFADD7282946 Q35317884-2FA0DEAE-5906-481D-B146-D2BA6B173B54 Q35854222-298D3CB8-CD27-461E-A594-A3DD2B5109DE Q36219461-5B1BF0AE-72AF-4659-A978-C91FF8085A15 Q36316869-43150157-7078-431C-AA72-5B9DE25C1593 Q36361268-C427C946-6E27-4B6C-BA87-0092E2DE8546 Q36499724-3464B521-2012-466C-AF5C-63384AEC0026 Q37009087-FA1F74AD-5D4B-42C3-83D4-C8B1567010DA Q37219104-9B24A392-0358-4361-BB73-E211BFB3E4EC Q37355850-4060B3B9-6E93-4964-92CA-12B524EE92F3 Q37392438-F1164B99-CC00-4BE7-8FFA-F25CBD0DDAD4 Q37596197-C2EF7DFF-2CE2-482E-AECE-F820939A3C32 Q37696175-6C17B923-B2FE-4536-9343-4ACECB488BE1 Q37865870-3393C3B3-8A76-402E-9E0E-3C820F383CB3 Q38042443-693539B0-B6FE-48A5-9C7B-B96933A4B53C Q38175465-13EA2BD0-0C5A-4614-B64C-92404611752D Q38220772-40120FE4-4FEE-459A-9122-AA6E94BB4F04 Q38247635-4425EC9A-4365-4185-882D-416832292BAD Q38443368-970CF452-ABCA-42DB-A685-C354E0E92703 Q38580461-D6FCB6F2-4D4C-474A-AAF5-3643FD27FCE4 Q38800585-CE6143B6-8AED-4015-9337-9AC6BA66E94E Q38837216-1BB04445-ECC7-479E-9053-5CDD19D253E5 Q38902371-580E0D80-702E-41C3-968D-DD93CFDA1DC7 Q38970261-F1AB4C65-536E-4703-AB7C-2E7390B88137 Q38973987-A15EDE32-15C1-428C-8F0F-BC4F9AC8535F Q38997142-DA5E7FD7-A390-4BC7-A5B4-18C5EB7E604F Q39110979-E5E3BCA0-8136-410A-977B-5DE52FFD4FFA Q39180227-809948C2-D214-47A1-8387-5330854F2D98 Q39218226-CAE9C05E-D42B-48EC-AA46-B4FE7DF5B5CF Q39236344-174DDA26-0CF3-45F2-9ECE-7D687E21DA40 Q40200602-594C2B27-3ECF-4049-961F-8D1D9B62A2B6 Q41651767-2CDE7C22-AC30-4D82-B039-09EB63043F5A Q42223709-57C0E3E7-05DA-4551-9CBE-C980D1B647E9 Q42369905-B428DCD6-B498-42A9-B6E3-089ECF26F004 Q42470563-5D71C0D1-AD1E-4D37-9072-631A09297274

P2860

Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib.

http://www.wikidata.org/entity/Q54618750

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年学术文章

@wuu

2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

2011年學術文章

@zh

2011年學術文章

@zh-hant

name

Inhibition of PDGF, TGF-β, and ...... e kinase antagonist Nilotinib.

@en

Inhibition of PDGF, TGF-β, and ...... e kinase antagonist Nilotinib.

@nl

type

label

Inhibition of PDGF, TGF-β, and ...... e kinase antagonist Nilotinib.

@en

Inhibition of PDGF, TGF-β, and ...... e kinase antagonist Nilotinib.

@nl

prefLabel

Inhibition of PDGF, TGF-β, and ...... e kinase antagonist Nilotinib.

@en

Inhibition of PDGF, TGF-β, and ...... e kinase antagonist Nilotinib.

@nl

P1433

Q54618750-51DD0440-5634-4481-B5AA-DA8083ED95FE

P1476

Q54618750-4955C92C-05F4-442D-99B4-7F503E3C1FFC

P2093

Q54618750-3492DFA0-B9D6-43D3-B9C3-F6F558FF58B0

Q54618750-4298235E-6070-41B1-872C-A6AFEE9B5F11

Q54618750-6340A4BC-DFE0-4E8B-B7B3-1C5F80D3181B

Q54618750-846AC08C-BA3C-4F06-B7F4-B03A843F73FE

Q54618750-9183598B-8CDE-4AE8-8AB4-9FCF3A86A30B

Q54618750-AD8AAFE5-6F87-45A0-BE36-ED580AB27895

Q54618750-AE6E4E85-AE60-46B3-A0D7-A366AA9CF963

Q54618750-C1FF9064-58BE-4CB9-BFF8-7A93B6188FAB

Q54618750-C604BF04-3823-4F08-897A-F6FB90397EB0

Q54618750-CF1C1768-15D0-4714-8BAD-D06CBFA5C697

P304

Q54618750-7E9943A6-8666-441B-B8AA-AA2D1E02F95C

P31

Q54618750-618441E9-227D-4CC3-9B7D-AC6AA0DECC04

P356

Q54618750-9155ABA9-D5E8-49FF-BD79-E5ABAF65159C

P433

Q54618750-B28F1E62-7E9A-41B2-B633-88076A0F4C14

P478

Q54618750-D0E7CB42-3A05-4988-9F10-57503C734751

P577

Q54618750-1D3A76A7-8506-4AA6-AFF1-D0C717051698

P5875

Q54618750-7A158CBE-187B-4B87-9DD5-EB92050BB078

P698

Q54618750-E8A2E09A-4ED2-42E2-8BA9-98E942CA5F9B

P356

J.JHEP.2010.11.035

P1433

Journal of Hepatology

P1476

Inhibition of PDGF, TGF-β, and ...... e kinase antagonist Nilotinib.

@en

P2093

Eric Lik Hang Lui

http://www.w3.org/2001/XMLSchema#string

Fu Rong Li

http://www.w3.org/2001/XMLSchema#string

Guo Chao Zhang

http://www.w3.org/2001/XMLSchema#string

Hui Zhang

http://www.w3.org/2001/XMLSchema#string

Reni Wing Chi Lam

http://www.w3.org/2001/XMLSchema#string

Scott L Friedman

http://www.w3.org/2001/XMLSchema#string

Shu Qin Kwong

http://www.w3.org/2001/XMLSchema#string

Tao Ye

http://www.w3.org/2001/XMLSchema#string

Yuqing Liu

http://www.w3.org/2001/XMLSchema#string

Zhuo Wang

http://www.w3.org/2001/XMLSchema#string

P304

612-625

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.JHEP.2010.11.035

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

55

http://www.w3.org/2001/XMLSchema#string

P577

2011-01-18T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

49771558

http://www.w3.org/2001/XMLSchema#string

P698

21251937

http://www.w3.org/2001/XMLSchema#string