EPR stopped-flow studies of the reaction of the tyrosyl radical of protein R2 from ribonucleotide reductase with hydroxyurea.
about
Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclaseImplication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage responseA new mechanism-based radical intermediate in a mutant R1 protein affecting the catalytically essential Glu441 in Escherichia coli ribonucleotide reductaseThe Cell Killing Mechanisms of HydroxyureaHigh-content, image-based screening for drug targets in yeastMethyl-hydroxylamine as an efficacious antibacterial agent that targets the ribonucleotide reductase enzymeRibonucleotide reductase metallocofactor: assembly, maintenance and inhibition.Nucleotide metabolism, oncogene-induced senescence and cancer.Two distinct mechanisms of inactivation of the class Ic ribonucleotide reductase from Chlamydia trachomatis by hydroxyurea: implications for the protein gating of intersubunit electron transfer.Phase I study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia.A functional approach reveals a genetic and physical interaction between ribonucleotide reductase and CHK1 in mammalian cells.Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells.Hydroxyurea: a key player in cancer chemotherapy.Rapid flip-flop of phospholipids in endoplasmic reticulum membranes studied by a stopped-flow approach.Redox-linked changes to the hydrogen-bonding network of ribonucleotide reductase β2.Redox-linked conformational control of proton-coupled electron transfer: Y122 in the ribonucleotide reductase β2 subunit.Induction of the mouse ribonucleotide reductase R1 and R2 genes in response to DNA damage by UV light.Rapid kinetics of insertion and accessibility of spin-labeled phospholipid analogs in lipid membranes: a stopped-flow electron paramagnetic resonance approach.Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease.Reduction of the tyrosyl radical and the iron center in protein R2 of ribonucleotide reductase from mouse, herpes simplex virus and E. coli by p-alkoxyphenols.Preserved catalytic activity in an engineered ribonucleotide reductase R2 protein with a nonphysiological radical transfer pathway. The importance of hydrogen bond connections between the participating residues.Disruption of an oligomeric interface prevents allosteric inhibition of Escherichia coli class Ia ribonucleotide reductase.Kinetics of transient radicals in Escherichia coli ribonucleotide reductase. Formation of a new tyrosyl radical in mutant protein R2.Transient free radicals in iron/oxygen reconstitution of mutant protein R2 Y122F. Possible participants in electron transfer chains in ribonucleotide reductase.
P2860
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P2860
EPR stopped-flow studies of the reaction of the tyrosyl radical of protein R2 from ribonucleotide reductase with hydroxyurea.
description
1992 nî lūn-bûn
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1992年の論文
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1992年学术文章
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1992年学术文章
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1992年学术文章
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1992年學術文章
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name
EPR stopped-flow studies of th ...... de reductase with hydroxyurea.
@en
EPR stopped-flow studies of th ...... de reductase with hydroxyurea.
@nl
type
label
EPR stopped-flow studies of th ...... de reductase with hydroxyurea.
@en
EPR stopped-flow studies of th ...... de reductase with hydroxyurea.
@nl
prefLabel
EPR stopped-flow studies of th ...... de reductase with hydroxyurea.
@en
EPR stopped-flow studies of th ...... de reductase with hydroxyurea.
@nl
P1476
EPR stopped-flow studies of th ...... de reductase with hydroxyurea.
@en
P2093
Lassmann G
Thelander L
P304
P356
10.1016/0006-291X(92)91138-G
P407
P577
1992-10-01T00:00:00Z