A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors.
about
Therapeutic implications of bioactive sphingolipids: A focus on colorectal cancer."Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer.The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer.Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo.Sphingolipid metabolism in cancer signalling and therapy.Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT.The combination of a sphingosine kinase 2 inhibitor (ABC294640) and a Bcl-2 inhibitor (ABT-199) displays synergistic anti-myeloma effects in myeloma cells without a t(11;14) translocation.Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3.Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seqTypical and Atypical Inducers of Lysosomal Cell Death: A Promising Anticancer Strategy
P2860
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P2860
A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors.
description
2017 nî lūn-bûn
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2017年の論文
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年學術文章
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name
A Phase I Study of ABC294640, ...... ts with Advanced Solid Tumors.
@en
A Phase I Study of ABC294640, ...... ts with Advanced Solid Tumors.
@nl
type
label
A Phase I Study of ABC294640, ...... ts with Advanced Solid Tumors.
@en
A Phase I Study of ABC294640, ...... ts with Advanced Solid Tumors.
@nl
prefLabel
A Phase I Study of ABC294640, ...... ts with Advanced Solid Tumors.
@en
A Phase I Study of ABC294640, ...... ts with Advanced Solid Tumors.
@nl
P2093
P2860
P1476
A Phase I Study of ABC294640, ...... ts with Advanced Solid Tumors.
@en
P2093
Alan Brisendine
Besim Ogretmen
Carolyn D Britten
Charles D Smith
Elizabeth Garrett-Mayer
Kate Anderton
Keisuke Shirai
Lynn W Maines
Melanie B Thomas
Steven H Chin
P2860
P304
P356
10.1158/1078-0432.CCR-16-2363
P407
P577
2017-04-18T00:00:00Z