Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.
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Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertensionIloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungsThe effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP-receptorRegulation of prostacyclin and prostaglandin E(2) receptor mediated responses in adult rat dorsal root ganglion cells, in vitroProstacyclin receptor-independent inhibition of phospholipase C activity by non-prostanoid prostacyclin mimeticsA Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalizationProtein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes.The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.Internalization and sequestration of the human prostacyclin receptor.Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6.Role of prostacyclin in pulmonary hypertension.Prostacyclin signaling in the kidney: implications for health and disease.Prostacyclin receptor regulation--from transcription to trafficking.Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively.Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor.Agonist-dependent internalization and trafficking of the human prostacyclin receptor: a direct role for Rab5a GTPaseDimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation.Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation.Investigation of the mechanisms of G protein: effector coupling by the human and mouse prostacyclin receptors. Identification of critical species-dependent differences.Agonist-induced long-term desensitization of the human prostacyclin receptor.Delayed reversal of shape change in cells expressing FP(B) prostanoid receptors. Possible role of receptor resensitization.The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for prostacyclin-mediated desensitization.G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells.Receptor phosphorylation does not mediate cross talk between muscarinic M(3) and bradykinin B(2) receptors.Properties of chimeric prostacyclin/prostaglandin D2 receptors: site-directed mutagenesis reveals the significance of the isoleucine residue at position 323.
P2860
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P2860
Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Phosphorylation of the prostac ...... cal role for protein kinase c.
@en
Phosphorylation of the prostac ...... cal role for protein kinase c.
@nl
type
label
Phosphorylation of the prostac ...... cal role for protein kinase c.
@en
Phosphorylation of the prostac ...... cal role for protein kinase c.
@nl
prefLabel
Phosphorylation of the prostac ...... cal role for protein kinase c.
@en
Phosphorylation of the prostac ...... cal role for protein kinase c.
@nl
P2093
P2860
P356
P1476
Phosphorylation of the prostac ...... cal role for protein kinase c.
@en
P2093
P2860
P304
23258-23266
P356
10.1074/JBC.273.36.23258
P407
P577
1998-09-01T00:00:00Z