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Insights into domain-domain motions in proteins and RNA from solution NMRX-ray structures of binary and ternary enzyme-product-inhibitor complexes of matrix metalloproteinasesExploring the subtleties of drug-receptor interactions: the case of matrix metalloproteinasesEvidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12Biotin-tagged probes for MMP expression and activation: design, synthesis, and binding propertiesEntropic contribution to the linking coefficient in fragment based drug design: a case studyStructure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs)The catalytic domain of MMP-1 studied through tagged lanthanidesStructural basis for matrix metalloproteinase 1-catalyzed collagenolysis.Solution structure and dynamics of human S100A14Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studiesUnraveling hidden regulatory sites in structurally homologous metalloproteases"Four-dimensional" protein structures: examples from metalloproteins.Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors.NMR of sedimented, fibrillized, silica-entrapped and microcrystalline (metallo)proteins.Differences in Dynamics between Crosslinked and Non-Crosslinked Hyaluronates Measured by using Fast Field-Cycling Relaxometry.In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases.Conformational variability of matrix metalloproteinases: beyond a single 3D structure.NMR-based techniques in the hit identification and optimisation processes.Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity.Examination of matrix metalloproteinase-1 in solution: a preference for the pre-collagenolysis state.G-triplex structure and formation propensity.Biosilica-Entrapped Enzymes Studied by Using Dynamic Nuclear-Polarization-Enhanced High-Field NMR Spectroscopy.Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold.Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy.Interdomain flexibility in full-length matrix metalloproteinase-1 (MMP-1).(1)H-detected solid-state NMR of proteins entrapped in bioinspired silica: a new tool for biomaterials characterization.NMR characterization of the C-terminal tail of full-length RAGE in a membrane mimicking environment.Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au (111) surfaces monitored by ESI-MS.Atomic structural details of a protein grafted onto gold nanoparticles.Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors.Long-range paramagnetic NMR data can provide a closer look on metal coordination in metalloproteins.Methyl group assignment using pseudocontact shifts with PARAssign.Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).Paramagnetic metal ions in ligand screening: the Co(II) matrix metalloproteinase 12.Regulation of HuR structure and function by dihydrotanshinone-I.Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity.High-Resolution Solid-State NMR Characterization of Ligand Binding to a Protein Immobilized in a Silica Matrix.Paramagnetic Properties of a Crystalline Iron-Sulfur Protein by Magic-Angle Spinning NMR Spectroscopy.Solid-State NMR of PEGylated Proteins.
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Marco Fragai
@ast
Marco Fragai
@en
Marco Fragai
@es
Marco Fragai
@nl
Marco Fragai
@sl
type
label
Marco Fragai
@ast
Marco Fragai
@en
Marco Fragai
@es
Marco Fragai
@nl
Marco Fragai
@sl
prefLabel
Marco Fragai
@ast
Marco Fragai
@en
Marco Fragai
@es
Marco Fragai
@nl
Marco Fragai
@sl
P106
P1153
6602534343
P21
P31
P496
0000-0002-8440-1690