Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824).

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Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824).

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2018 nî lūn-bûn

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2018年学术文章

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2018年学术文章

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Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824).

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Untargeted metabolomics reveals a new mode of action of pretomanid

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Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824).

@en

Untargeted metabolomics reveals a new mode of action of pretomanid

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Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824).

@en

Untargeted metabolomics reveals a new mode of action of pretomanid

@nl

P1476

Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824)

@en

P2093

David M Fazakerley

http://www.w3.org/2001/XMLSchema#string

Manfred Beckmann

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P2860

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

Mechanisms of action of isoniazid

Two mechanisms for growth inhibition by elevated transport of sugar phosphates in Escherichia coli.

Critical role of methylglyoxal and AGE in mycobacteria-induced macrophage apoptosis and activation.

Metabolite signal identification in accurate mass metabolomics data with MZedDB, an interactive m/z annotation tool utilising predicted ionisation behaviour 'rules'.

Comparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver.

P304

5084

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scholarly article

P356

10.1038/S41598-018-23110-1

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P407

English

P433

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P478

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P50

Luis A.J. Mur

Les Baillie

Rafael Baptista

P577

2018-03-23T00:00:00Z

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P698

29572459

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P932

5865180

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