about
The Membrane Steps of Bacterial Cell Wall Synthesis as Antibiotic TargetsActivities and regulation of peptidoglycan synthasesSite-specific functionalization of proteins and their applications to therapeutic antibodiesNMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activityCalcium-dependent complex formation between PBP2 and lytic transglycosylase SltB1 of Pseudomonas aeruginosaSpecificity of the transport of lipid II by FtsW in Escherichia coliSmall molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor.Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membraneEnhanced membrane pore formation through high-affinity targeted antimicrobial peptides.New Insights into Nisin's Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues.The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics.Fluorescent labeling of nisin Z and assessment of anti-listerial action.Lipid II: a central component in bacterial cell wall synthesis and a target for antibiotics.Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase.Polyene antibiotic that inhibits membrane transport proteins.Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II.Lipid II as a target for antibiotics.The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN.A lesson in efficient killing from two-component lantibiotics.Expanding role of lipid II as a target for lantibiotics.Specific labeling of peptidoglycan precursors as a tool for bacterial cell wall studies.Membrane permeabilization by multivalent anti-microbial peptides.The chlamydial anomaly clarified?Mapping the targeted membrane pore formation mechanism by solution NMR: the nisin Z and lipid II interaction in SDS micelles.Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol.Hit 'em where it hurts: The growing and structurally diverse family of peptides that target lipid-II.Role of lipid II and membrane thickness in the mechanism of action of the lantibiotic bovicin HC5.Membrane interaction of the glycosyltransferase MurG: a special role for cardiolipin.A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses.Importance of the conserved residues in the peptidoglycan glycosyltransferase module of the class A penicillin-binding protein 1b of Escherichia coli.Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesisSynthesis and antifungal properties of papulacandin derivatives.Interaction with lipid II induces conformational changes in bovicin HC5 structure.Regulation of peptidoglycan synthesis by outer-membrane proteins.Molecular model for the solubilization of membranes into nanodisks by styrene maleic Acid copolymers.Cell biology. Lethal traffic jam.Clavanin permeabilizes target membranes via two distinctly different pH-dependent mechanisms.Lipid II induces a transmembrane orientation of the pore-forming peptide lantibiotic nisin.Getting closer to the real bacterial cell wall target: biomolecular interactions of water-soluble lipid II with glycopeptide antibiotics.Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes.
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Eefjan Breukink
@ast
Eefjan Breukink
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Eefjan Breukink
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Eefjan Breukink
@nl
Eefjan Breukink
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type
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Eefjan Breukink
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Eefjan Breukink
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Eefjan Breukink
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Eefjan Breukink
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Eefjan Breukink
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Eefjan Breukink
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Eefjan Breukink
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Eefjan Breukink
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Eefjan Breukink
@nl
Eefjan Breukink
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P106
P31
P496
0000-0002-7311-0660