about
The attachment (G) glycoprotein of respiratory syncytial virus contains a single immunodominant epitope that elicits both Th1 and Th2 CD4+ T cell responses.Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells.Sensitive detection and quantitation of mouse eosinophils in tissues using an enzymatic eosinophil peroxidase assay: its use to rapidly measure pulmonary eosinophilia during experimental respiratory syncytial virus infection of mice.RSV-induced immunopathology: dynamic interplay between the virus and host immune response.Determining the breadth of the respiratory syncytial virus-specific T cell responseRespiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17.Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replicationProliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infectionFas ligand is required for the development of respiratory syncytial virus vaccine-enhanced diseaseThe number of respiratory syncytial virus (RSV)-specific memory CD8 T cells in the lung is critical for their ability to inhibit RSV vaccine-enhanced pulmonary eosinophilia.Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virusVbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSVLimitations of Foxp3(+) Treg depletion following viral infection in DEREG mice.Effects of aging on the adaptive immune response to respiratory virus infections.Mucosal vaccines against respiratory syncytial virusT cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts.The pulmonary localization of virus-specific T lymphocytes is governed by the tissue tropism of infection.Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infectionEffects of formalin-inactivated respiratory syncytial virus (FI-RSV) in the perinatal lamb model of RSV.Depletion of alveolar macrophages ameliorates virus-induced disease following a pulmonary coronavirus infection.RSV vaccine-enhanced disease is orchestrated by the combined actions of distinct CD4 T cell subsetsQuantifying antigen-specific CD4 T cells during a viral infection: CD4 T cell responses are larger than we think.Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infectionInflammatory IL-15 is required for optimal memory T cell responses.Understanding respiratory syncytial virus (RSV) vaccine-enhanced disease.Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination.Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus.Comparison of histochemical methods for murine eosinophil detection in an RSV vaccine-enhanced inflammation model.Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.Human respiratory syncytial virus A2 strain replicates and induces innate immune responses by respiratory epithelia of neonatal lambs.The relationship between respiratory syncytial virus and asthma.The CD4 T cell response to respiratory syncytial virus infection.Viral manipulation of the host immune response.Modulation of the host immune response by respiratory syncytial virus proteins.Host genetics play a critical role in controlling CD8 T cell function and lethal immunopathology during chronic viral infection.Sirolimus alters lung pathology and viral load following influenza A virus infection.CD11a and CD49d enhance the detection of antigen-specific T cells following human vaccination.Altered Treg and cytokine responses in RSV-infected infants.Evaluation of the Adaptive Immune Response to Respiratory Syncytial Virus.
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Steven M Varga
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Steven M Varga
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Steven M Varga
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Steven M Varga
@nl
Steven M Varga
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type
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Steven M Varga
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Steven M Varga
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Steven M Varga
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Steven M Varga
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Steven M Varga
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prefLabel
Steven M Varga
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Steven M Varga
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Steven M Varga
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Steven M Varga
@nl
Steven M Varga
@sl
P106
P21
P31
P496
0000-0001-7332-4290