about
PEX5S;L binds cargo proteins containing PTS1PEX5S;L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)Cargo of PEX5S;L translocates from the cytosol to the peroxisomal matrixPEX2:PEX10:PEX12:Ub:PEX5S;L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S;L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S;L and membrane PEX14:PEX13:PEX2:PEX10:PEX12USP9X binds Ub:PEX5SUSP9X hydrolyzes Ub:PEX5S yielding PEX5S and UbiquitinPEX7 binds cargo proteins containing PTS2PEX5L binds PEX7:Cargo proteinPEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrixPEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1;2;3PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosolUSP9X binds Ub:PEX5LUSP9X hydrolyzes Ub:PEX5L yielding PEX5L and UbiquitinTYSND1 cleaves peroxisomal proteins
P361
Q55217635-A9934F1B-BCAD-445F-85CE-3DDC01BE544DQ55217637-474BB43E-F44C-42A2-9D7E-DDDDB2BEBF01Q55217640-59E5DE27-1355-4B18-B3C3-73E4E994D086Q55217642-80C9F45E-DFB3-44B3-9AF4-14AF440610CFQ55217643-E5C6C035-DB8A-4981-A9DD-2D98492D069DQ55217645-AD5956A6-0E71-48A2-B441-1E04E8371416Q55217646-0702EA32-F2F0-4C99-8E40-103307127F04Q55217648-B46DD517-1FA0-4F4B-BF3A-DF1774F2B063Q55217649-6BE32B84-6857-4633-AE2A-437FA3D05550Q55217651-F8C36C6F-3AE1-4C13-B0CF-15946F89A869Q55217652-79337117-3390-4B62-A7C3-831BADF6388FQ55217653-76C5E94A-BB49-4AB8-8A3F-4913EB6D4BB3Q55217655-D9F068A7-512B-41F0-82AA-65CEDDCA2795Q55217656-E21BCBC8-0C0F-458E-A60A-0584DA5EB5DFQ55217658-8B15EBB0-0609-49EB-917A-75F839FCBD57Q55217659-F9661A48-83F7-46EA-8D11-DD4449D67512Q55217661-56AA503F-3F94-4E2D-B279-CF815DFCF86BQ55230829-7FECE8E5-E561-46E6-9A3F-043829B419C4
P361
description
An instance of the biological pathway Peroxisomal protein import in Homo sapiens
@en
name
Peroxisomal protein import
@en
type
label
Peroxisomal protein import
@en
prefLabel
Peroxisomal protein import
@en
P2860
P527
P2860
P3937
R-HSA-9033241