about
Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardationCDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndromeMethyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosisCDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tailMeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?MeCP2 Affects Skeletal Muscle Growth and Morphology through Non Cell-Autonomous MechanismsCDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machineryWhat we know and would like to know about CDKL5 and its involvement in epileptic encephalopathyMethyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organizationRemodeling of regulatory nucleoprotein complexes on the Xenopus hsp70 promoter during meiotic maturation of the Xenopus oocyteXenopus NF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from the Xenopus hsp70 promoter in vivoThe MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis.Synaptic synthesis, dephosphorylation, and degradation: a novel paradigm for an activity-dependent neuronal control of CDKL5CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization.MeCP2 Related Studies Benefit from the Use of CD1 as Genetic Background.Characterisation of CDKL5 Transcript Isoforms in Human and MouseBrain phosphorylation of MeCP2 at serine 164 is developmentally regulated and globally alters its chromatin associationRett syndrome and the urge of novel approaches to study MeCP2 functions and mechanisms of action.ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy.Autocrine and immune cell-derived BDNF in human skeletal muscle: implications for myogenesis and tissue regeneration.Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.Chromatin and transcriptional activity in early Xenopus development.CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.Spatio-temporal dynamics and localization of MeCP2 and pathological mutants in living cells.Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity.A novel protein, Xenopus p20, influences the stability of MeCP2 through direct interaction.The cDNA encoding Xenopus laevis heat-shock factor 1 (XHSF1): nucleotide and deduced amino-acid sequences, and properties of the encoded protein.The neurosteroid pregnenolone reverts microtubule derangement induced by the loss of a functional CDKL5-IQGAP1 complex.Incorporation of mouse zona pellucida proteins into the envelope of Xenopus laevis oocytes.A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain.Phylogenetic study of bisexual Artemia using random amplified polymorphic DNA.Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction: Atomistic characterization of a Rett syndrome causing mutation.Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency DisorderA Novel Mecp2 Knock-in Model Displays Similar Behavioral Traits But Distinct Molecular Features Compared to the Mecp2-Null Mouse Implying Precision Medicine for the Treatment of Rett SyndromeA binding protein (p82 protein) recognizes specifically the curved heterochromatic DNA in Artemia franciscanaNucleotide variation and molecular structure of the heterochromatic repetitive AluI DNA in the brine shrimp Artemia franciscana
P50
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P50
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onderzoeker
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հետազոտող
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Nicoletta Landsberger
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Nicoletta Landsberger
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Nicoletta Landsberger
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Nicoletta Landsberger
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Nicoletta Landsberger
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Nicoletta Landsberger
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Nicoletta Landsberger
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Nicoletta Landsberger
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Nicoletta Landsberger
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Nicoletta Landsberger
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Nicoletta Landsberger
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Nicoletta Landsberger
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Nicoletta Landsberger
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P106
P1153
6603941648
P31
P496
0000-0003-0820-3155