about
Guidance for data collection and computational modelling of regulatory networksChemical decay of an antibiotic inverts selection for resistance.Transcriptional interference by RNA polymerase pausing and dislodgement of transcription factors.Opposing effects of target overexpression reveal drug mechanismsDelayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environmentsOvercoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors.Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance.Chemical probes: The many genes of drug mechanism.The role of repressor kinetics in relief of transcriptional interference between convergent promoters.Potent transcriptional interference by pausing of RNA polymerases over a downstream promoter.Directing traffic on DNA-How transcription factors relieve or induce transcriptional interference.Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy.Regulatory Dynamics Determine Cell Fate following Abrupt Antibiotic Exposure.Modeling the impact of drug interactions on therapeutic selectivityA curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivityNonoptimal Gene Expression Creates Latent Potential for Antibiotic ResistanceAdaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic ReprogrammingRNA polymerase pausing at a protein roadblock can enhance transcriptional interference by promoter occlusionBiomarker-driven strategy for MCL1 inhibition in T-cell lymphomas
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Adam C. Palmer
@ast
Adam C. Palmer
@en
Adam C. Palmer
@es
Adam C. Palmer
@nl
Adam C. Palmer
@sl
آدم سي. بالمر
@ar
type
label
Adam C. Palmer
@ast
Adam C. Palmer
@en
Adam C. Palmer
@es
Adam C. Palmer
@nl
Adam C. Palmer
@sl
آدم سي. بالمر
@ar
prefLabel
Adam C. Palmer
@ast
Adam C. Palmer
@en
Adam C. Palmer
@es
Adam C. Palmer
@nl
Adam C. Palmer
@sl
آدم سي. بالمر
@ar
P106
P1153
16639022400
P21
P31
P496
0000-0001-5028-7028