about
Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBPThe tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive propertiesThe human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif.HIC1 interacts with a specific subunit of SWI/SNF complexes, ARID1A/BAF250ARecruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-BO-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group ProteinsRETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complexAn acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activityIdentification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1Chromosome arm 17p13.3: could HIC1 be the one ?The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conservedNovel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogeneThe transcription factor encyclopediaThe human DNA locus related to the oncogene myb of avian myeloblastosis virus (AMV): molecular cloning and structural characterization.A putative second cell-derived oncogene of the avian leukaemia retrovirus E26.The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain.A residue of the ETS domain mutated in the v-ets oncogene is essential for the DNA-binding and transactivating properties of the ETS-1 and ETS-2 proteins.The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1).Loss of Hypermethylated in Cancer 1 (HIC1) in breast cancer cells contributes to stress-induced migration and invasion through β-2 adrenergic receptor (ADRB2) misregulation.Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoproteinMolecular cloning and characterization of the chicken DNA locus related to the oncogene erbB of avian erythroblastosis virusMultiple domains for the chicken cellular sequences homologous to the v-ets oncogene of the E26 retrovirus.Deciphering HIC1 control pathways to reveal new avenues in cancer therapeutics.Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4+ T-Cell ActivationHIC1 (Hypermethylated in Cancer 1) epigenetic silencing in tumorsRequirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control.HIC1 interacts with and modulates the activity of STAT3.Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1).Implication of HIC1 (Hypermethylated In Cancer 1) in the DNA damage response.HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).p54c-ets-1 and p68c-ets-1, the two transcription factors encoded by the c-ets-1 locus, are differentially expressed during the development of the chick embryo.HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage-Associated Tumorigenesis.The Reelin receptors ApoER2 and VLDLR are direct target genes of HIC1 (Hypermethylated In Cancer 1).Identification of p21 (CIP1/WAF1) as a direct target gene of HIC1 (Hypermethylated In Cancer 1).Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair.The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1.Multiple domains participate in distance-independent LAZ3/BCL6-mediated transcriptional repression.
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description
hulumtuese
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researcher
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հետազոտող
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
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Dominique Leprince
@sl
P106
P21
P31
P496
0000-0002-1999-0775