Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition. - Wikidata - wikimedia - TriplyDB

Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition.

Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition.

http://www.wikidata.org/entity/Q55417340

about

Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization.Geoepidemiology and Immunologic Features of Autoinflammatory Diseases: a Comprehensive Review.Pediatric acute liver failure of undetermined cause: A research workshop.The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases.New frontiers in the treatment of systemic juvenile idiopathic arthritis.The role of monogenic disease in children with very early onset inflammatory bowel disease.Genomics, Biology, and Human Illness: Advances in the Monogenic Autoinflammatory Diseases.The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation.A novel Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis mutation further defines 14-3-3 binding of pyrin and distinction to Familial Mediterranean Fever.Lytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1β release.Hyperferritinemia and inflammation.Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasome.NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease.Overview of the IL-1 family in innate inflammation and acquired immunity.Interleukin-18: Biological properties and role in disease pathogenesis.NLRC4 inflammasomopathies.Weathering the storm: Improving therapeutic interventions for cytokine storm syndromes by targeting disease pathogenesis.The NLRC4 Inflammasome.Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β.Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome.Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease.The role of IL-1 inhibition in systemic juvenile idiopathic arthritis: current status and future perspectives.The classification, genetic diagnosis and modelling of monogenic autoinflammatory disorders Rapamycin as an Adjunctive Therapy for NLRC4 Associated Macrophage Activation Syndrome Anakinra Therapy for Non-cancer Inflammatory Diseases

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P2860

Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition.

http://www.wikidata.org/entity/Q55417340

description

2016 nî lūn-bûn

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2016年の論文

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年學術文章

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2016年學術文章

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2016年學術文章

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name

Life-threatening NLRC4-associa ...... treated with IL-18 inhibition.

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Life-threatening NLRC4-associa ...... treated with IL-18 inhibition.

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type

label

Life-threatening NLRC4-associa ...... treated with IL-18 inhibition.

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Life-threatening NLRC4-associa ...... treated with IL-18 inhibition.

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prefLabel

Life-threatening NLRC4-associa ...... treated with IL-18 inhibition.

@en

Life-threatening NLRC4-associa ...... treated with IL-18 inhibition.

@nl

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J.JACI.2016.10.022

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The Journal of Allergy and Clinical Immunology

P1476

Life-threatening NLRC4-associa ...... treated with IL-18 inhibition.

@en

P2093

Adriana de Jesus

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Andrew Sleight

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Charlotte Girard

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Eduardo Schiffrin

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Edward M Behrens

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Judith Kelsen

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Lea F Surrey

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Louise Malle

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Neil Romberg

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Pierre Russo

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P2860

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis.

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation.

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)

Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling.

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder.

Increased serum levels of interferon-gamma-inducible protein 10 and monokine induced by gamma interferon in patients with haemophagocytic lymphohistiocytosis.

Elevated serum levels of free interleukin-18 in adult-onset Still's disease.

Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis.

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1698-1701

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