sameAs
Biotechnology. A prudent path forward for genomic engineering and germline gene modificationMitotic spindle destabilization and genomic instability in Shwachman-Diamond syndromeTelomere elongation in induced pluripotent stem cells from dyskeratosis congenita patientsMusashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemiaSelective blockade of microRNA processing by Lin28The Lin28/let-7 axis regulates glucose metabolismLin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studiesDifferential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblastsNovel role for PDEF in epithelial cell migration and invasionMetabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survivalDisease-specific induced pluripotent stem cellsDown's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1Farnesyl transferase inhibitor resistance probed by target mutagenesisA screen to identify drug resistant variants to target-directed anti-cancer agentsChronic myeloid leukemia: reminiscences and dreamsAdenosine signaling promotes hematopoietic stem and progenitor cell emergence.Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment.Activation of tyrosine kinases by mutation of the gatekeeper threonineTargeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitorsHighly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.High-efficiency RNA interference in human embryonic stem cellsGenetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regenerationTargeted and genome-scale strategies reveal gene-body methylation signatures in human cellsReprogramming of human somatic cells to pluripotency with defined factorsLin28: primal regulator of growth and metabolism in stem cellsComprehensive methylome map of lineage commitment from haematopoietic progenitorsLin28 enhances tissue repair by reprogramming cellular metabolismTet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cellsCritical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cellsLin28 sustains early renal progenitors and induces Wilms tumorThe Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activityThe homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiationA role for Lin28 in primordial germ-cell development and germ-cell malignancyMidbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicityAcceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factorSomatic coding mutations in human induced pluripotent stem cellsLin28a regulates germ cell pool size and fertility.A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence.A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling.A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells.
P50
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P50
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