about
Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locusThe M-type receptor PLA2R regulates senescence through the p53 pathwayEpigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in healthChemokine signaling via the CXCR2 receptor reinforces senescenceMouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatinNcoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogrammingAn adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation.PRC1 complex diversity: where is it taking us?Ageing as developmental decay: insights from p16(INK4a.).Role of the chromobox protein CBX7 in lymphomagenesis.Role of polycomb group proteins in stem cell self-renewal and cancer.Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expressionInduction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosisSynthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors.CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a).TRIM28/KAP1 regulates senescence.Co-regulation of senescence-associated genes by oncogenic homeobox proteins and polycomb repressive complexes.Immunization with recombinant DNA and modified vaccinia virus Ankara (MVA) vectors delivering PSCA and STEAP1 antigens inhibits prostate cancer progression.Mitochondria and senescence: new actors for an old play.A genetic screen identifies topoisomerase 1 as a regulator of senescence.The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes.The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-alpha receptors.Vaccinia virus E3L protein is an inhibitor of the interferon (i.f.n.)-induced 2-5A synthetase enzyme.Controlling secretion to limit chemoresistance.Primary cilia and senescence: a sensitive issue.Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved.HMGB2 holds the key to the senescence-associated secretory phenotype.Anti-apoptotic and oncogenic properties of the dsRNA-binding protein of vaccinia virus, E3L.Identification of functional domains of the interferon-induced enzyme PKR in cells lacking endogenous PKR.TORn about SASP regulation.CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus.Caspase 9 activation by the dsRNA-dependent protein kinase, PKR: molecular mechanism and relevance.DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts.Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.Senescence and aging: Causes, consequences, and therapeutic avenues.An Epigenetic Switch: From Senescent Melanocytes to Malignant Melanoma (and Back).The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-kappaB activation.Mechanisms and functions of cellular senescence.
P50
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P50
description
onderzoeker
@nl
researcher ORCID: 0000-0002-4303-6260
@en
name
J Gil
@ast
J Gil
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J Gil
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J Gil
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J Gil
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type
label
J Gil
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J Gil
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J Gil
@es
J Gil
@nl
J Gil
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prefLabel
J Gil
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J Gil
@en
J Gil
@es
J Gil
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J Gil
@sl
P106
P1153
7201625551
P31
P496
0000-0002-4303-6260