about
An autoinhibitory effect of the homothorax domain of Meis2Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.The Tgif2 gene contains a retained intron within the coding sequence.Multimerization of Hsp42p, a novel heat shock protein of Saccharomyces cerevisiae, is dependent on a conserved carboxyl-terminal sequence.The polycomb protein Pc2 is a SUMO E3A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity.The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIFA Smad transcriptional corepressorMutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determinationThe Smad transcriptional corepressor TGIF recruits mSin3TGIF2 interacts with histone deacetylase 1 and represses transcriptionPremature senescence and increased TGFβ signaling in the absence of Tgif1.The Runx3 distal transcript encodes an additional transcriptional activation domainTGIF inhibits retinoid signalingdSno facilitates baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2.Transcriptional control by the TGF-beta/Smad signaling systemSUMO and Chromatin Remodeling.Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.Smad transcriptional corepressors in TGF beta family signaling.TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2.Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis.Tgif1 regulates quiescence and self-renewal of hematopoietic stem cellsProstate cancer induced by loss of Apc is restrained by TGFβ signalingCooperative transcriptional activation by Klf4, Meis2, and Pbx1Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.Tgif1 represses apolipoprotein gene expression in liver.A rapid strategy to detect the recombined allele in LSL-TβRICA transgenic mice.Inhibition of CtBP1 activity by Akt-mediated phosphorylation.Multiple activities contribute to Pc2 E3 function.The Sno oncogene antagonizes Wingless signaling during wing development in DrosophilaMaternal Tgif is required for vascularization of the embryonic placentaPc2 and SUMOylation.Drosophila TGIF proteins are transcriptional activators.TGF-β drives DNA demethylation.A CREB1-TGFβ2 self-sustaining loop in glioblastoma.Determinants of specificity in TGF-beta signal transduction.Cooperative binding of Ets-1 and core binding factor to DNAThe protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.
P50
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P50
description
researcher
@en
wetenschapper
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հետազոտող
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name
David Wotton
@de
David Wotton
@en
David Wotton
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David Wotton
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David Wotton
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David Wotton
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type
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David Wotton
@de
David Wotton
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David Wotton
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David Wotton
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David Wotton
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David Wotton
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D Wotton
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David Wotton
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David Wotton
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David Wotton
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David Wotton
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David Wotton
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David Wotton
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P106
P21
P31
P496
0000-0002-4652-5350