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Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome.Helium-Neon laser irradiation of hepatocytes can trigger increase of the mitochondrial membrane potential and can stimulate c-fos expression in a Ca2+-dependent manner.Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme.Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols.Increase of both transcription and translation activities following separate irradiation of the in vitro system components with He-Ne laser.Increase in cytosolic and mitochondrial protein synthesis in rat hepatocytes irradiated in vitro by He-Ne laser.Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: an overview of Down syndrome, autism, Fragile X and Rett syndrome.3-Bromopyruvate induces rapid human prostate cancer cell death by affecting cell energy metabolism, GSH pool and the glyoxalase system.Plant polyphenols as natural drugs for the management of Down syndrome and related disorders.Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy.The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model.Proteasome function is required for activation of programmed cell death in heat shocked tobacco Bright-Yellow 2 cells.In the early phase of programmed cell death in Tobacco Bright Yellow 2 cells the mitochondrial adenine nucleotide translocator, adenylate kinase and nucleoside diphosphate kinase are impaired in a reactive oxygen species-dependent manner.Production of reactive oxygen species, alteration of cytosolic ascorbate peroxidase, and impairment of mitochondrial metabolism are early events in heat shock-induced programmed cell death in tobacco Bright-Yellow 2 cells.Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo.Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway.Negative modulation of mitochondrial oxidative phosphorylation by epigallocatechin-3 gallate leads to growth arrest and apoptosis in human malignant pleural mesothelioma cells.Thyroid hormone administration to hypothyroid rats restores the mitochondrial membrane permeability properties.Preservation of mitochondrial functional integrity in mitochondria isolated from small cryopreserved mouse brain areas.Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome.Mitochondrial free radical overproduction due to respiratory chain impairment in the brain of a mouse model of Rett syndrome: protective effect of CNF1.A transient proteasome activation is needed for acetic acid-induced programmed cell death to occur in Saccharomyces cerevisiae.Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration.Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention.Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model.Mitochondria as pharmacological targets in Down syndrome.Modulation of Rho GTPases rescues brain mitochondrial dysfunction, cognitive deficits and aberrant synaptic plasticity in female mice modeling Rett syndrome.Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism.Green tea EGCG plus fish oil omega-3 dietary supplements rescue mitochondrial dysfunctions and are safe in a Down's syndrome child.Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome.Active-site Arg --> Lys substitutions alter reaction and substrate specificity of aspartate aminotransferase.Molecular basis of cystic fibrosis in Lithuania: incomplete CFTR mutation detection by PCR-based screening protocols.Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency DisorderImport of mutant forms of mitochondrial aspartate aminotransferase into isolated mitochondriaTargeting BDNF signaling by natural products: Novel synaptic repair therapeutics for neurodegeneration and behavior disordersBrain-Immune Alterations and Mitochondrial Dysfunctions in a Mouse Model of Paediatric Autoimmune Disorder Associated with Streptococcus: Exacerbation by Chronic Psychosocial StressTargeting STATs in neuroinflammation: The road less traveled!Down syndrome: Neurobiological alterations and therapeutic targetsComparison of the efficacy of gesture-verbal treatment and doll therapy for managing neuropsychiatric symptoms in older patients with dementiaAberrant mitochondrial bioenergetics in the cerebral cortex of the Fmr1 knockout mouse model of fragile X syndrome
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P50
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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Rosa Anna Vacca
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6701582913
P21
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0000-0003-2438-6449