about
Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approachesEster derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors.Reduction of rat brain levels of the endogenous dopaminergic proneurotoxins 1,2,3,4-tetrahydroisoquinoline and 1,2,3,4-tetrahydro-beta-carboline by cigarette smoke.Searching for Multi-Targeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif.Copper increases the ability of 6-hydroxydopamine to generate oxidative stress and the ability of ascorbate and glutathione to potentiate this effect: potential implications in Parkinson's disease.Differential toxicity of 6-hydroxydopamine in SH-SY5Y human neuroblastoma cells and rat brain mitochondria: protective role of catalase and superoxide dismutase.In silico design of novel 2H-chromen-2-one derivatives as potent and selective MAO-B inhibitors.Reduction of dopaminergic degeneration and oxidative stress by inhibition of angiotensin converting enzyme in a MPTP model of parkinsonism.Effect of iron and manganese on hydroxyl radical production by 6-hydroxydopamine: mediation of antioxidants.Effects of aluminum and zinc on the oxidative stress caused by 6-hydroxydopamine autoxidation: relevance for the pathogenesis of Parkinson's disease.Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.Autoxidation and MAO-mediated metabolism of dopamine as a potential cause of oxidative stress: role of ferrous and ferric ions.Systemic administration of N-acetylcysteine protects dopaminergic neurons against 6-hydroxydopamine-induced degeneration.Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors.Brain oxidative stress and selective behaviour of aluminium in specific areas of rat brain: potential effects in a 6-OHDA-induced model of Parkinson's disease.Angiotensin-converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism.Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides.A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins.Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.High-performance liquid chromatographic procedure for quantitative determination of pentylenetetrazol in serum and discrete areas of rat brain.Time-course of brain oxidative damage caused by intrastriatal administration of 6-hydroxydopamine in a rat model of Parkinson's disease.Studies on the interaction between 1,2,3,4-tetrahydro-beta-carboline and cigarette smoke: a potential mechanism of neuroprotection for Parkinson's disease.Effects of Aluminium on Rat Brain Mitochondria Bioenergetics: an In vitro and In vivo Study.Discovery of a Novel Class of Potent Coumarin Monoamine Oxidase B Inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one Methanesulfonate (NW-1772) as a Highly Potent, Selective, RInteraction of 1,2,3,4-Tetrahydroisoquinoline with Some Components of Cigarette Smoke: Potential Implications for Parkinson's DiseaseAnalysis of brain regional distribution of aluminium in rats via oral and intraperitoneal administrationAutoxidation and Neurotoxicity of 6-Hydroxydopamine in the Presence of Some AntioxidantsReversed-phase high-performance liquid chromatography method for the determination of bemegride in serum and brain tissue: pharmacokinetics and brain distribution of an intraperitoneal subconvulsive dose in ratsExperimental spike-and-wave discharges induced by pentylenetetrazol and tolerance to repeated injections: an electrophysiological and biochemical studyThe effect of storage conditions on the stability of carbamazepine and carbamazepine-10,11-epoxide in plasmaInhibition of brain monoamine oxidase by adducts of 1,2,3,4-tetrahydroisoquinoline with components of cigarette smokeAntioxidant properties of dimethyl sulfoxide and its viability as a solvent in the evaluation of neuroprotective antioxidantsCopper Increases Brain Oxidative Stress and Enhances the Ability of 6-Hydroxydopamine to Cause Dopaminergic Degeneration in a Rat Model of Parkinson's Disease
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramon Soto-Otero
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Soto-Otero R
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramón Soto-Otero
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Ramón Soto-Otero
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P1053
H-7872-2015
P106
P1153
7004270645
P21
P31
P4012
P496
0000-0003-0079-0279
P569
2000-01-01T00:00:00Z