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Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorderX-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder.C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stressPhosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.Mitochondrial metals as a potential therapeutic target in neurodegeneration.Targeting mitochondrial metal dyshomeostasis for the treatment of neurodegeneration.Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.Nexus between mitochondrial function, iron, copper and glutathione in Parkinson's disease.Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm).Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?Astrocytes retain their antioxidant capacity into advanced old age.Copper modulates the large dense core vesicle secretory pathway in PC12 cells.Endogenous glutathione and catalase protect cultured rat astrocytes from the iron-mediated toxicity of hydrogen peroxide.Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.Sustained hydrogen peroxide stress decreases lactate production by cultured astrocytes.Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease.Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry.Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.Glutathione peroxidase 1 and a high cellular glutathione concentration are essential for effective organic hydroperoxide detoxification in astrocytes.Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.
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description
researcher
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wetenschapper
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հետազոտող
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name
Jeffrey R Liddell
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Jeffrey R Liddell
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Jeffrey R Liddell
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Jeffrey R Liddell
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Jeffrey R Liddell
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type
label
Jeffrey R Liddell
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Jeffrey R Liddell
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Jeffrey R Liddell
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Jeffrey R Liddell
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Jeffrey R Liddell
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Jeffrey R Liddell
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Jeffrey R Liddell
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Jeffrey R Liddell
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Jeffrey R Liddell
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Jeffrey R Liddell
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P106
P31
P496
0000-0002-0798-5338