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Preference of small molecules for local minimum conformations when binding to proteinsCharting a Path to Success in Virtual ScreeningThe crystal structure and mechanism of 1-L-myo-inositol- 1-phosphate synthaseStructural characterization of the closed conformation of mouse guanylate kinaseDifferential active site loop conformations mediate promiscuous activities in the lactonase SsoPoxIntegrating Nanostructured Artificial Receptors with Whispering Gallery Mode Optical Microresonators via Inorganic Molecular Imprinting TechniquesA Protein Data Bank survey reveals shortening of intermolecular hydrogen bonds in ligand-protein complexes when a halogenated ligand is an H-bond donorStatistical mechanical model of gas adsorption in porous crystals with dynamic moietiesMolecular simulations reveal that the long range fluctuations of human DPP III change upon ligand binding.Normal-mode-analysis-monitored energy minimization procedure for generating small-molecule bound conformations.A fast dynamic mode of the EF-G-bound ribosome.Describing sequence-ensemble relationships for intrinsically disordered proteins.Adaptive self-assembly and induced-fit transformations of anion-binding metal-organic macrocyclesSubstrate-induced conformational changes in human UMP/CMP kinase.Calcineurin A versus NS5A-TP2/HD domain containing 2: a case study of site-directed low-frequency random mutagenesis for dissecting target specificity of peptide aptamersArchitecture and mechanism of the central gear in an ancient molecular timer.Asymmetric effect of mechanical stress on the forward and reverse reaction catalyzed by an enzyme.Prechemistry versus preorganization in DNA replication fidelity.On the energy components governing molecular recognition in the framework of continuum approachesSupracolloidal Architectures Self-Assembled in Microdroplets.Flavonolignans As a Novel Class of Sodium Pump Inhibitors.Insertion of oxidized nucleotide triggers rapid DNA polymerase openingTargeting synuclein-gamma to counteract drug resistance in cancer.Why nature really chose phosphate.Glycosynthesis in a waterworld: new insight into the molecular basis of transglycosylation in retaining glycoside hydrolases.Protein Flexibility in Drug Discovery: From Theory to Computation.Conformational analysis of δ-lactones by DFT calculations: the parent compound and its monomethyl and selected dimethyl derivatives.What is so special about smell? Olfaction as a model system in neurobiology.Use of Integrated Computational Approaches in the Search for New Therapeutic Agents.Computational delineation of the catalytic step of a high-fidelity DNA polymerase.Molecular docking towards drug discovery.Sequence-based prediction of transcription upregulation by auxin in plants.Assembling oppositely charged lock and key responsive colloids: A mesoscale analog of adaptive chemistry.Analysis of c-Met kinase domain complexes: a new specific catalytic site receptor model for defining binding modes of ATP-competitive ligands.Site-directed mutagenesis of ATP binding residues of biotin carboxylase. Insight into the mechanism of catalysis.Lack of enantioselectivity in the SULT1A3-catalyzed sulfoconjugation of normetanephrine enantiomers: an in vitro and computational study.Performance of the MM/GBSA scoring using a binding site hydrogen bond network-based frame selection: the protein kinase case.Different protein-protein interface patterns predicted by different machine learning methods.Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes.Substrate distortion in the Michaelis complex of Bacillus 1,3-1,4-beta-glucanase. Insight from first principles molecular dynamics simulations.
P2860
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P2860
description
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 1995
@uk
name
The Key–Lock Theory and the Induced Fit Theory
@en
The Key–Lock Theory and the Induced Fit Theory
@nl
type
label
The Key–Lock Theory and the Induced Fit Theory
@en
The Key–Lock Theory and the Induced Fit Theory
@nl
prefLabel
The Key–Lock Theory and the Induced Fit Theory
@en
The Key–Lock Theory and the Induced Fit Theory
@nl
P356
P1476
The Key–Lock Theory and the Induced Fit Theory
@en
P2093
Daniel E. Koshland
P304
P356
10.1002/ANIE.199423751
P407
P577
1995-01-03T00:00:00Z