The Quasi-Steady-State Assumption: A Case Study in Perturbation
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A linear framework for time-scale separation in nonlinear biochemical systemsThe interplay of intrinsic and extrinsic bounded noises in biomolecular networksOrder reduction of the chemical master equation via balanced realisationEvaluation of rate law approximations in bottom-up kinetic models of metabolismLazy Updating of hubs can enable more realistic models by speeding up stochastic simulationsInvariance and optimality in the regulation of an enzyme.Reciprocal regulation as a source of ultrasensitivity in two-component systems with a bifunctional sensor kinase.Slowly produced microRNAs control protein levelsStiffness detection and reduction in discrete stochastic simulation of biochemical systems.Michaelis-Menten speeds up tau-leaping under a wide range of conditionsAccuracy of the Michaelis-Menten approximation when analysing effects of molecular noiseBayesian Estimation of the Active Concentration and Affinity Constants Using Surface Plasmon Resonance Technology.The relationship between stochastic and deterministic quasi-steady state approximations.Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone CalnexinSpatial reduction algorithm for atmospheric chemical transport modelsEfficiency of primary saliva secretion: an analysis of parameter dependence in dynamic single-cell and acinus models, with application to aquaporin knockout studies.Spatial simulations in systems biology: from molecules to cells.Driving the Model to Its Limit: Profile Likelihood Based Model ReductionThe Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems.A mathematical model of the dynamics of prion aggregates with chaperone-mediated fragmentationBiophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1.Oscillatory enzyme reactions and Michaelis-Menten kinetics.Clusters of reaction rates and concentrations in protein networks such as the phosphotransferase system.Dynamic membrane patterning, signal localization and polarity in living cells.The average enzyme principle.Modeling fructose-load-induced hepatic de-novo lipogenesis by model simplification.A Geometric Method for Model Reduction of Biochemical Networks with Polynomial Rate Functions.Adaptive deployment of model reductions for tau-leaping simulation.A method of ‘speed coefficients’ for biochemical model reduction applied to the NF-κB system.Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification.Impact of saturable distribution in compartmental PK models: dynamics and practical use.Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study.Simplifying biochemical models with intermediate species.Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations.Mathematical model of alternative mechanism of telomere length maintenance.Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology.Adaptive explicit-implicit tau-leaping method with automatic tau selection.Global stability of enzymatic chains of full reversible Michaelis-Menten reactions.Theoretical considerations of target-mediated drug disposition models: simplifications and approximations.Beyond the Michaelis-Menten equation: Accurate and efficient estimation of enzyme kinetic parameters.
P2860
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P2860
The Quasi-Steady-State Assumption: A Case Study in Perturbation
description
im September 1989 veröffentlicher wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 1989
@uk
name
The Quasi-Steady-State Assumption: A Case Study in Perturbation
@en
The Quasi-Steady-State Assumption: A Case Study in Perturbation
@nl
type
label
The Quasi-Steady-State Assumption: A Case Study in Perturbation
@en
The Quasi-Steady-State Assumption: A Case Study in Perturbation
@nl
prefLabel
The Quasi-Steady-State Assumption: A Case Study in Perturbation
@en
The Quasi-Steady-State Assumption: A Case Study in Perturbation
@nl
P356
P1433
P1476
The Quasi-Steady-State Assumption: A Case Study in Perturbation
@en
P2093
Lee A. Segel
Marshall Slemrod
P304
P356
10.1137/1031091
P577
1989-09-01T00:00:00Z