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Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin bindingA crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells.Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype.A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation.P marks the spot: site-specific integrin phosphorylation regulates molecular interactions.Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteinsInterfering with leukocyte integrin activation--a novel concept in the development of anti-inflammatory drugs.Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusRegulation of integrin activity and signallingCaveolin-1 Influences LFA-1 Redistribution upon TCR Stimulation in CD8 T Cells.Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.Optimal T Cell Activation and B Cell Antibody Responses In Vivo Require the Interaction between Leukocyte Function-Associated Antigen-1 and Kindlin-3.The β2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo.Filamin A Regulates Neutrophil Adhesion, Production of Reactive Oxygen Species, and Neutrophil Extracellular Trap Release.Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking.Functional Beta2-Integrins Restrict Skin Inflammation In VivoPhosphorylation of the LFA-1 Integrin β2-Chain on Thr-758 Leads to Adhesion, Rac-1/Cdc42 Activation, and Stimulation of CD69 Expression in Human T Cells14-3-3 Proteins Bind Both Filamin and Lbeta2 Integrin in Activated T Cells-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasationBeta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency DiseaseA β2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation.Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Susanna C Fagerholm
@ast
Susanna C Fagerholm
@en
Susanna C Fagerholm
@es
Susanna C Fagerholm
@nl
Susanna C Fagerholm
@sl
type
label
Susanna C Fagerholm
@ast
Susanna C Fagerholm
@en
Susanna C Fagerholm
@es
Susanna C Fagerholm
@nl
Susanna C Fagerholm
@sl
prefLabel
Susanna C Fagerholm
@ast
Susanna C Fagerholm
@en
Susanna C Fagerholm
@es
Susanna C Fagerholm
@nl
Susanna C Fagerholm
@sl
P106
P21
P31
P496
0000-0002-0354-8763