about
Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlKSecond-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assemblySynthesis of structurally defined scaffolds for bivalent ligand display based on glucuronic acid anilides. The degree of tertiary amide isomerism and folding depends on the configuration of a glycosyl azide.Chemical probes for the functionalization of polyketide intermediates.Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes.Chemical probing of thiotetronate bio-assembly.The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase.Novel chemical probes for the investigation of nonribosomal peptide assembly.Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles.N-Glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types.A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis.Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase.In vitro reconstruction of tetronate RK-682 biosynthesis.Insights into protein-protein and enzyme-substrate interactions in modular polyketide synthases.Synthetic chain terminators off-load intermediates from a type I polyketide synthase.A study of the epoxidation of 6-deoxyhex-5-enopyranosides. 1,5-Dicarbonyl derivatives and novel synthetic routes to D-xylo-hexos-5-ulose and D-lyxo-hexos-5-ulose.Glycosidation reactions of silyl ethers with conformationally inverted donors derived from glucuronic acid: stereoselective synthesis of glycosides and 2-deoxyglycosides.Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates.Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters.Synthesis and structural analysis of the anilides of glucuronic acid and orientation of the groups on the carbohydrate scaffolding.Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases.Insights into lasalocid A ring formation by chemical chain termination in vivo.Insights into the stereospecificity of ketoreduction in a modular polyketide synthase.In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines.Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discoveryHigh-Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and Polyketide AnalysisStructural Characterization of Polyketides Using High Mass Accuracy Tandem Mass SpectrometryCorrigendum to “Synthesis of sugar-lactams from azides of glucuronic acid”Glycosidation–Anomerisation Reactions of 6,1-Anhydroglucopyranuronic Acid and Anomerisation of β-D-Glucopyranosiduronic Acids Promoted by SnCl4Synthesis of sugar-lactams from azides of glucuronic acidThe synthesis of cyclic imidates from amides of glucuronic acid and investigation of glycosidation reactionsSynthesis of Structurally Diverse and Defined Bivalent Mannosides on Saccharide ScaffoldingDevelopment of Carbohydrate-Based Scaffolds for Restricted Presentation of Recognition Groups. Extension to Divalent Ligands and Implications for the Structure of Dimerized ReceptorsSynthesis of α-Glucuronic Acid and Amide Derivatives in the Presence of a Participating 2-Acyl Protecting GroupNovel Synthesis of the Glycosidase Inhibitor Deoxymannojirimycin and of a Synthetic Precursord-lyxo-Hexos-5-uloseA Light-Activated Acyl Carrier Protein "Trap" for Intermediate Capture in Type II Iterative Polyketide BiocatalysisA Photoactivatable Small-Molecule Probe for the In Vivo Capture of Polyketide Intermediates
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Manuela Tosin
@ast
Manuela Tosin
@en
Manuela Tosin
@es
Manuela Tosin
@nl
Manuela Tosin
@sl
type
label
Manuela Tosin
@ast
Manuela Tosin
@en
Manuela Tosin
@es
Manuela Tosin
@nl
Manuela Tosin
@sl
prefLabel
Manuela Tosin
@ast
Manuela Tosin
@en
Manuela Tosin
@es
Manuela Tosin
@nl
Manuela Tosin
@sl
P106
P1153
6701799884
P21
P31
P496
0000-0003-4340-9431