about
Energetically significant networks of coupled interactions within an unfolded proteinThe unfolded state of the villin headpiece helical subdomain: computational studies of the role of locally stabilized structureLow levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: implications for the study of amyloid formationSolution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II.Domain-specific incorporation of noninvasive optical probes into recombinant proteins.De novo design of helical bundles as models for understanding protein folding and function.Selenomethionine, p-cyanophenylalanine pairs provide a convenient, sensitive, non-perturbing fluorescent probe of local helical structure.Modulation of p-cyanophenylalanine fluorescence by amino acid side chains and rational design of fluorescence probes of alpha-helix formation.Azidohomoalanine: a conformationally sensitive IR probe of protein folding, protein structure, and electrostatics.Selenomethionine Quenching of Tryptophan Fluorescence Provides a Simple Probe of Protein Structure.Azido Homoalanine is a Useful Infrared Probe for Monitoring Local Electrostatistics and Sidechain Solvation in Proteins.Cooperative cold denaturation: the case of the C-terminal domain of ribosomal protein L9.Synthesis and purification of amyloidogenic peptides.Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins.High Pressure ZZ-Exchange NMR Reveals Key Features of Protein Folding Transition States.Partially folded equilibrium intermediate of the villin headpiece HP67 defined by 13C relaxation dispersion.Electrostatic interactions in the denatured state ensemble: their effect upon protein folding and protein stabilityAnalysis of the Amyloidogenic Potential of Pufferfish (Takifugu rubripes) Islet Amyloid Polypeptide Highlights the Limitations of Thioflavin-T Assays and the Difficulties in Defining AmyloidogenicityNeprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation.Sensitivity of amyloid formation by human islet amyloid polypeptide to mutations at residue 20Effect of modulating unfolded state structure on the folding kinetics of the villin headpiece subdomainNucleobindin 1 is a calcium-regulated guanine nucleotide dissociation inhibitor of G{alpha}i1.Analysis of the inhibition and remodeling of islet amyloid polypeptide amyloid fibers by flavanolsRationally designed, nontoxic, nonamyloidogenic analogues of human islet amyloid polypeptide with improved solubilityMorin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers.Defining the molecular basis of amyloid inhibitors: human islet amyloid polypeptide-insulin interactions.Raising the speed limit for β-hairpin formation.Efficient microwave-assisted synthesis of human islet amyloid polypeptide designed to facilitate the specific incorporation of labeled amino acids.The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity.Residue-specific, real-time characterization of lag-phase species and fibril growth during amyloid formation: a combined fluorescence and IR study of p-cyanophenylalanine analogs of islet amyloid polypeptideScreening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry.Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction.Mutational analysis of the ability of resveratrol to inhibit amyloid formation by islet amyloid polypeptide: critical evaluation of the importance of aromatic-inhibitor and histidine-inhibitor interactionsIon mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitorsMutational analysis of preamyloid intermediates: the role of his-tyr interactions in islet amyloid formationGeneral amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers.Tuning protein autoinhibition by domain destabilizationDetection of Helical Intermediates During Amyloid Formation by Intrinsically Disordered Polypeptides and Proteins.In Vitro Studies of Membrane Permeability Induced by Amyloidogenic Polypeptides Using Large Unilamellar Vesicles.The protein folding transition state: what are Phi-values really telling us?
P50
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P50
description
researcher
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researcher
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wetenschapper
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հետազոտող
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name
Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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Daniel P Raleigh
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P106
P21
P31
P496
0000-0003-3248-7493