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Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndromeDeletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene.Complement and diseases: defective alternative pathway control results in kidney and eye diseases.Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions.Hemolytic uremic syndrome: a factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells.Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome.Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency.Factor H family proteins and human diseases.Autoimmune forms of thrombotic microangiopathy and membranoproliferative glomerulonephritis: Indications for a disease spectrum and common pathogenic principles.Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome.Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome.Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome.Complement factor H-antibody-associated hemolytic uremic syndrome: pathogenesis, clinical presentation, and treatment.The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model for induction of autoimmunity in this disease.Heterogeneity but individual constancy of epitopes, isotypes and avidity of factor H autoantibodies in atypical hemolytic uremic syndrome.Factor H Family Proteins in Complement Evasion of Microorganisms.Human pentraxin 3 binds to the complement regulator c4b-binding protein.Neutrophil activation during attacks in patients with hereditary angioedema due to C1-inhibitor deficiencySelectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients.The C-terminus of complement factor H is essential for host cell protection.Analysis of Linear Antibody Epitopes on Factor H and CFHR1 Using Sera of Patients with Autoimmune Atypical Hemolytic Uremic Syndrome.Factor H-related proteins.Factor h: a complement regulator in health and disease, and a mediator of cellular interactions.Factor H-related proteins determine complement-activating surfaces.Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18).Factor H inhibits complement activation induced by liposomal and micellar drugs and the therapeutic antibody rituximab in vitro.Complement factor H modulates the activation of human neutrophil granulocytes and the generation of neutrophil extracellular traps.Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation.Pathogenic Leptospira species acquire factor H and vitronectin via the surface protein LcpA.The Murine Factor H-Related Protein FHR-B Promotes Complement ActivationFactor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity.FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.Functional Characterization of the Disease-Associated N-Terminal Complement Factor H Mutation W198R.Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils.Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4.Leptospiral Immunoglobulin-like Proteins Interact With Human Complement Regulators Factor H, FHL-1, FHR-1, and C4BPC3 glomerulopathy - understanding a rare complement-driven renal disease
P50
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P50
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P106
P31
P496
0000-0002-5520-5535