about
Cardiolipin signaling mechanisms: collapse of asymmetry and oxidationEssential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart functionThe antioxidant requirement for plasma membrane repair in skeletal muscleInactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in miceCytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac developmentNeuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegenerationEpididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant miceSec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2.Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growthThe role of thioredoxin reductases in brain development.Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsyEuropean contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).Oxidized arachidonic and adrenic PEs navigate cells to ferroptosisT cell lipid peroxidation induces ferroptosis and prevents immunity to infection.12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy.Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation.Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferationHuman thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration.Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals.Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.Mitochondrial glutathione peroxidase 4 disruption causes male infertility.Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages.Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility.Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium.Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2.Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degenerationThioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsivenessSelective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling.Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4.Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies.The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons.The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-) : cystine supplier and beyond.Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability.Glutathione and thioredoxin dependent systems in neurodegenerative disease: what can be learned from reverse genetics in mice.ROS, thiols and thiol-regulating systems in male gametogenesis.Thiol switches in mitochondria: operation and physiological relevance.Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-Mediated Cell Death after Hepatic Ischemia and Reperfusion.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Marcus Conrad
@ast
Marcus Conrad
@en
Marcus Conrad
@es
Marcus Conrad
@nl
type
label
Marcus Conrad
@ast
Marcus Conrad
@en
Marcus Conrad
@es
Marcus Conrad
@nl
prefLabel
Marcus Conrad
@ast
Marcus Conrad
@en
Marcus Conrad
@es
Marcus Conrad
@nl
P106
P1153
7202541824
P21
P31
P496
0000-0003-1140-5612