UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

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UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity

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http://www.wikidata.org/entity/Q56534093

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im Juli 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 18 July 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в липні 2018

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name

UBE3A-mediated p18/LAMTOR1 ubi ...... tivity and synaptic plasticity

@en

UBE3A-mediated p18/LAMTOR1 ubi ...... tivity and synaptic plasticity

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UBE3A-mediated p18/LAMTOR1 ubi ...... tivity and synaptic plasticity

@en

UBE3A-mediated p18/LAMTOR1 ubi ...... tivity and synaptic plasticity

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prefLabel

UBE3A-mediated p18/LAMTOR1 ubi ...... tivity and synaptic plasticity

@en

UBE3A-mediated p18/LAMTOR1 ubi ...... tivity and synaptic plasticity

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P1476

UBE3A-mediated p18/LAMTOR1 ubi ...... tivity and synaptic plasticity

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P2093

Gary Lynch

http://www.w3.org/2001/XMLSchema#string

Jennifer Tran

http://www.w3.org/2001/XMLSchema#string

Michel Baudry

http://www.w3.org/2001/XMLSchema#string

Xiaoning Hao

http://www.w3.org/2001/XMLSchema#string

Yan Liu

http://www.w3.org/2001/XMLSchema#string

Yousheng Jia

http://www.w3.org/2001/XMLSchema#string

P2860

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

mTOR signaling in growth control and disease

Autism or atypical autism in maternally but not paternally derived proximal 15q duplication

Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

P31

scholarly article

P356

10.7554/ELIFE.37993

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P407

English

P478

http://www.w3.org/2001/XMLSchema#string

P50

Wei Ju Lin

Jiandong Sun

Xiaoning Bi

P577

2018-07-18T00:00:00Z

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P698

30020076

http://www.w3.org/2001/XMLSchema#string

P921

protein ubiquitination

P932

6063731

http://www.w3.org/2001/XMLSchema#string