about
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosineBaicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitorExploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substratesSelenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicityThe role of peptides in blood-brain barrier nanotechnology.Bicyclic homodetic peptide libraries: comparison of synthetic strategies for their solid-phase synthesis.Solid-phase synthesis and characterization of N-methyl-rich peptides.Evolutionary combinatorial chemistry, a novel tool for SAR studies on peptide transport across the blood-brain barrier. Part 2. Design, synthesis and evaluation of a first generation of peptides.Diketopiperazines as a tool for the study of transport across the blood-brain barrier (BBB) and their potential use as BBB-shuttles.Toward an optimal blood-brain barrier shuttle by synthesis and evaluation of peptide libraries.Novel peptidyl aryl vinyl sulfones as highly potent and selective inhibitors of cathepsins L and B.Dual system for the central nervous system targeting and blood-brain barrier transport of a selective prolyl oligopeptidase inhibitor.Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor.Cyclic Dipeptide Shuttles as a Novel Skin Penetration Enhancement Approach: Preliminary Evaluation with DiclofenacBifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic PainShuttle-mediated drug delivery to the brain.Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery.Blood-brain barrier peptide shuttles.Solid-phase-assisted synthesis of targeting peptide-PEG-oligo(ethane amino)amides for receptor-mediated gene delivery.Design, synthesis and characterization of a new anionic cell-penetrating peptide: SAP(E).MiniAp-4: A Venom-Inspired Peptidomimetic for Brain Delivery.Sequence-activity relationship, and mechanism of action of mastoparan analogues against extended-drug resistant Acinetobacter baumannii.N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles.Effect of the efflux pump inhibitor Phe-Arg-beta-naphthylamide on the MIC values of the quinolones, tetracycline and chloramphenicol, in Escherichia coli isolates of different origin.Chemical Composition and Inhibitory Effects of Hypericum brasiliense and H. connatum on Prolyl Oligopeptidase and Acetylcholinesterase Activities.Lipid bilayer crossing--the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttles.Applying the retro-enantio approach to obtain a peptide capable of overcoming the blood-brain barrier.Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor.Chemically synthesized peptide libraries as a new source of BBB shuttles. Use of mass spectrometry for peptide identification.From venoms to BBB shuttles: Synthesis and blood-brain barrier transport assessment of apamin and a nontoxic analog.'À la carte' peptide shuttles: tools to increase their passage across the blood-brain barrier.d-Polyarginine Lipopeptides as Intestinal Permeation EnhancersDoes the Solid-Phase Synthesis of a Tetrapeptide Represent a Challenge at the Onset of the XXI Century? The Case of Cyclo [(3R)-3-hydroxydecanoyl-l-seryl-(3R)-3-hydroxydecanoyl-l-seryl]Development of a Genetic Algorithm to Design and Identify Peptides that can Cross the Blood-Brain BarrierBranched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood-brain barrier transport.A pyridinium-substituted analog of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agentsExpanding the MiniAp-4 BBB-shuttle family: Evaluation of proline cis-trans ratio as tool to fine-tune transport
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Meritxell Teixidó
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