N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Pa
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Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitisInternational Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyCalcium influx pathways in breast cancer: opportunities for pharmacological interventionPharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic miceTransient receptor potential channels as therapeutic targetsTRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasisFacilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populationsTRPV channels and vascular functionThe Concise Guide to PHARMACOLOGY 2013/14: ion channelsOptical recording reveals novel properties of GSK1016790A-induced vanilloid transient receptor potential channel TRPV4 activity in primary human endothelial cells.TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses.Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscleThe primary cilium functions as a mechanical and calcium signaling nexusTRPM8 is a neuronal osmosensor that regulates eye blinking in mice.The puzzle of TRPV4 channelopathies.Transient receptor potential (TRP) channels: a clinical perspectiveTRPV4 mediates flow-induced increases in intracellular Ca in medullary thick ascending limbs.Integrin α1β1 participates in chondrocyte transduction of osmotic stressEmerging Families of Ion Channels Involved in Urinary Bladder Nociception.Calcineurin/nuclear factor of activated T cells-coupled vanilliod transient receptor potential channel 4 ca2+ sparklets stimulate airway smooth muscle cell proliferationImpairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanismDeterminants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A.Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutationsForward genetic analysis reveals multiple gating mechanisms of TRPV4Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD.The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivoIntravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male ratsBladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function.TRPV4 activation mediates flow-induced nitric oxide production in the rat thick ascending limb.Angiotensin II induces membrane trafficking of natively expressed transient receptor potential vanilloid type 4 channels in hypothalamic 4B cellsVascular TRP channels: performing under pressure and going with the flowReceptors, channels, and signalling in the urothelial sensory system in the bladderThe polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cellsTRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice.Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4TRPV4 and K(Ca) ion channels functionally couple as osmosensors in the paraventricular nucleusAxonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth.PKCα mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system.17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception.
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N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Pa
description
article
@en
im Mai 2008 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в травні 2008
@uk
ലേഖനം
@ml
name
N-((1S)-1- -3-hydroxypropanoyl ...... traction and Hyperactivity: Pa
@en
N-((1S)-1- -3-hydroxypropanoyl ...... traction and Hyperactivity: Pa
@nl
type
label
N-((1S)-1- -3-hydroxypropanoyl ...... traction and Hyperactivity: Pa
@en
N-((1S)-1- -3-hydroxypropanoyl ...... traction and Hyperactivity: Pa
@nl
prefLabel
N-((1S)-1- -3-hydroxypropanoyl ...... traction and Hyperactivity: Pa
@en
N-((1S)-1- -3-hydroxypropanoyl ...... traction and Hyperactivity: Pa
@nl
P2093
P356
P1476
N-((1S)-1-{[4-((2S)-2-{[(2,4-d ...... tion and hyperactivity: Part I
@en
P2093
Angela K Clouse
Anthony C Sulpizio
Bartholomew J Votta
Blake A Misajet
David J Figueroa
David P Brooks
Douglas J Demarini
Earl Gordon
Erin S R Lashinger
Gerald P McCafferty
P304
P356
10.1124/JPET.108.139295
P407
P577
2008-05-22T00:00:00Z