Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformationAn MHC class Ib-restricted CD8 T cell response confers antiviral immunityQa-region class I gene expression: identification of a second class I gene, Q9, encoding a Qa-2 polypeptideEmbryonal carcinoma cells express Qa and Tla class I genes of the major histocompatibility complex.Regulation of murine class I genes by interferons is controlled by regions located both 5' and 3' to the transcription initiation site.Expression of the thymidylate synthetase gene of the Bacillus subtilis bacteriophage Phi-3-T in Escherichia coli.Alternative splicing of class Ib major histocompatibility complex transcripts in vivo leads to the expression of soluble Qa-2 molecules in murine blood.Transcription termination at the tryptophan operon attenuator is decreased in vitro by an oligomer complementary to a segment of the leader transcriptDistribution of bacteriophage phi 3T homologous deoxyribonucleic acid sequences in Bacillus subtilis 168, related bacteriophages, and other Bacillus species.Integration of the bacteriophage phi 3T-coded thymidylate synthetase gene into the Bacillus subtilis chromosome.Expression and T cell recognition of hybrid antigens with amino-terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens.On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes.The alpha 3 domain of the Qa-2 molecule is defective for CD8 binding and cytotoxic T lymphocyte activation.A nonpolymorphic major histocompatibility complex class Ib molecule binds a large array of diverse self-peptidesQa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes.Differences between the lateral organization of conventional and inositol phospholipid-anchored membrane proteins. A further definition of micrometer scale membrane domainsExpression of hybrid class I genes of the major histocompatibility complex in mouse L cellsTranscription termination in vitro at the tryptophan operon attenuator is controlled by secondary structures in the leader transcript.Molecules related to class-I major histocompatibility complex antigens.Activated T cells transcribe an alternatively spliced mRNA encoding a soluble form of Qa-2 antigen.Isoforms of the nonclassical class I MHC antigen H2-Q5 are enriched in brain and encode Qdm peptide.The role of structurally conserved class I MHC in tumor rejection: contribution of the Q8 locus.The murine family of gut-restricted class Ib MHC includes alternatively spliced isoforms of the proposed HLA-G homolog, "blastocyst MHC".Protective immunity against disparate tumors is mediated by a nonpolymorphic MHC class I molecule.A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor.Novel molecules related to MHC antigens.Correction of defects responsible for impaired Qa-2 class Ib MHC expression on melanoma cells protects mice from tumor growth.Antigen presentation by non-classical class I molecules.Widespread expression of the nonclassical class I Qa-2 antigens in hemopoietic and nonhemopoietic cells.The murine liver-specific nonclassical MHC class I molecule Q10 binds a classical peptide repertoire.Multiple products of class Ib Qa-2 genes which ones are functional?Alternative peptide binding motifs of Qa-2 class Ib molecules define rules for binding of self and nonself peptides.Tissue-specific, peptide-binding transplantation antigens: lessons from the Qa-2 system.TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man.Aglycosylated and phosphatidylinositol-anchored MHC class I molecules are associated with calnexin. Evidence implicating the class I-connecting peptide segment in calnexin association.H-2Kb antigen expression has no effect on natural killer susceptibility and tumorigenicity of a murine hepatoma.Expression of secreted and glycosylphosphatidylinositol-bound Qa-2 molecules is dependent on functional TAP-2 peptide transporter.Characterization of mitochondrial DNA in chloramphenicol-resistant interspecific hybrids and a cybrid.Regulation of gene expression by interferons: control of H-2 promoter responses.Epitope clusters of Qa-2 antigens defined by a panel of new monoclonal antibodies.
P50
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P50
description
Polish-American immunologist (born 1950)
@en
Pools wetenschapster
@nl
name
Iwona Stroynowski
@ast
Iwona Stroynowski
@es
Iwona Stroynowski
@ga
Iwona Stroynowski
@nl
Iwona Stroynowski
@sl
Iwona Stroynowski
@sq
Iwona T. Stroynowski
@en
type
label
Iwona Stroynowski
@ast
Iwona Stroynowski
@es
Iwona Stroynowski
@ga
Iwona Stroynowski
@nl
Iwona Stroynowski
@sl
Iwona Stroynowski
@sq
Iwona T. Stroynowski
@en
altLabel
I Stroynowski
@en
I T Stroynowski
@en
I. Stroynowski
@en
I. T. Stroynowski
@en
Iwona Stroynowski
@en
Iwona T Stroynowski
@en
Iwona Teresa Fleszar
@en
Iwona Teresa Stroynowski
@en
Stroynowski I
@en
Stroynowski I. T.
@en
prefLabel
Iwona Stroynowski
@ast
Iwona Stroynowski
@es
Iwona Stroynowski
@ga
Iwona Stroynowski
@nl
Iwona Stroynowski
@sl
Iwona Stroynowski
@sq
Iwona T. Stroynowski
@en
P21
P31
P569
1950-08-08T00:00:00Z
P6634
iwona-stroynowski-49a8ba10