Insights into signaling from the β2-adrenergic receptor structure
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Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observationsThe 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonistConserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray CrystallographyPredicting novel binding modes of agonists to β adrenergic receptors using all-atom molecular dynamics simulationsAgent-based spatiotemporal simulation of biomolecular systems within the open source MASON framework.Structure-based discovery of beta2-adrenergic receptor ligands.Ligand and structure-based models for the prediction of ligand-receptor affinities and virtual screenings: Development and application to the beta(2)-adrenergic receptorLigand-directed signalling at beta-adrenoceptorsMapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach.Breast cancer resistance protein (BCRP/ABCG2) localises to the nucleus in glioblastoma multiforme cells.Antitumor activity of (R,R')-4-methoxy-1-naphthylfenoterol in a rat C6 glioma xenograft model in the mouseDocking-based virtual screening for ligands of G protein-coupled receptors: not only crystal structures but also in silico models.Development of 7TM receptor-ligand complex models using ligand-biased, semi-empirical helix-bundle repacking in torsion space: application to the agonist interaction of the human dopamine D2 receptor.Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity.Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition processThe design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists.Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system.G Protein-Coupled Receptor Trafficking and Signalling in the Enteric Nervous System: The Past, Present and Future.Mechanisms of propranolol action in infantile hemangiomaCannabinoid receptor activation correlates with the proapoptotic action of the β2-adrenergic agonist (R,R')-4-methoxy-1-naphthylfenoterol in HepG2 hepatocarcinoma cellsAgonist pharmacology at recombinant α1A - and α1L -adrenoceptors and in lower urinary tract α1 -adrenoceptors.Comparative analysis of GPCR crystal structures.β2-Adrenoceptor agonists in the regulation of mitochondrial biogenesis.Combining label-free cell phenotypic profiling with computational approaches for novel drug discovery.HIF-1alpha links beta-adrenoceptor agonists and pancreatic cancer cells under normoxic condition.Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.Overview of computational methods employed in early-stage drug discovery.Allosteric Communication Networks in Proteins Revealed through Pocket Crosstalk AnalysisToward the three-dimensional structure and lysophosphatidic acid binding characteristics of the LPA(4)/p2y(9)/GPR23 receptor: a homology modeling study.Homology model and docking studies on porcine β₂ adrenoceptor: description of two binding sites.In silico study of the structurally similar ORL1 receptor agonist and antagonist pairs reveal possible mechanism of receptor activation.Structure and Modeling of GPCRs: Implications for Drug DiscoveryGPCRs: Lipid-Dependent Membrane Receptors That Act as Drug Targets
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P2860
Insights into signaling from the β2-adrenergic receptor structure
description
im Juli 2008 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в липні 2008
@uk
name
Insights into signaling from the β2-adrenergic receptor structure
@en
Insights into signaling from the β2-adrenergic receptor structure
@nl
type
label
Insights into signaling from the β2-adrenergic receptor structure
@en
Insights into signaling from the β2-adrenergic receptor structure
@nl
prefLabel
Insights into signaling from the β2-adrenergic receptor structure
@en
Insights into signaling from the β2-adrenergic receptor structure
@nl
P356
P1476
Insights into signaling from the β2-adrenergic receptor structure
@en
P2093
Martin Audet
P2888
P304
P356
10.1038/NCHEMBIO.97
P577
2008-07-01T00:00:00Z