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Considering new methodologies in strategies for safety assessment of foods and food ingredientsKinetics of the formation and secretion of the aniline metabolite 4-aminophenol and its conjugates by isolated rat hepatocytesThe integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic as modelling a tool in hazard and risk assessment. A commentary.The long and winding road of progress in the use of in vitro data for risk assessment purposes: From "carnation test" to integrated testing strategies.Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling.Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity.The contribution of in vitro toxicity data in hazard and risk assessment: current limitations and future perspectives.13th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies and conceptual issues.On the incorporation of chemical-specific information in risk assessment.Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectors.Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice.Toward in vitro biomarkers for developmental toxicity and their extrapolation to the in vivo situation.A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals.Replacing the NIH test for rabies vaccine potency testing: a synopsis of drivers and barriers.An alkaline phosphatase transport mechanism in the pathogenesis of Alzheimer's disease and neurodegeneration.Stem cell-derived systems in toxicology assessment.Biokinetics in repeated-dosing in vitro drug toxicity studies.Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure.Regulatory acceptance and use of serology for inactivated veterinary rabies vaccines.Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing.In vitro testing of basal cytotoxicity: Establishment of an adverse outcome pathway from chemical insult to cell death.In vitro neuroendocrine effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the AhR-expressing hypothalamic rat GnV-3 cell line.In vitro biokinetics of chlorpromazine and the influence of different dose metrics on effect concentrations for cytotoxicity in Balb/c 3T3, Caco-2 and HepaRG cell cultures.Quantifying processes determining the free concentration of phenanthrene in Basal cytotoxicity assays.The European Registered Toxicologist (ERT): Current status and prospects for advancement.Excessive levels of diverse phytoestrogens can modulate steroidogenesis and cell migration of KGN human granulosa-derived tumor cells.Immunohistochemical detection of cytochrome P450 isoenzymes in cultured human epidermal cells.The need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiativeDecrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites.Transport of chlorpromazine in the Caco-2 cell permeability assay: a kinetic study.A novel hypothesis for an alkaline phosphatase 'rescue' mechanism in the hepatic acute phase immune response.Acid reaction products of indole-3-carbinol and their effects on cytochrome P450 and phase II enzymes in rat and monkey hepatocytes.Development of a negligible depletion-solid phase microextraction method to determine the free concentration of chlorpromazine in aqueous samples containing albumin.Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.Sens-it-iv: a European Union project to develop novel tools for the identification of skin and respiratory sensitizers.Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.Towards toxicity assessment without animals: 28th Workshop of SSCT and FINCOPA seminar 21-23 September 2011, Tampere, Finland.The in vitro biokinetics of chlorpromazine and diazepam in aggregating rat brain cell cultures after repeated exposure.Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: expert opinions on the state of affairs and the way forward.
P50
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P50
description
onderzoeker
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researcher
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հետազոտող
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name
Bas Blaauboer
@nl
Bas J Blaauboer
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Bas J Blaauboer
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Bas Blaauboer
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Bas J Blaauboer
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Bas J Blaauboer
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B. Blaauboer
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B.J. Blaauboer
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Bas Blaauboer
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Bas J Blaauboer
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Bas J Blaauboer
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P1153
7003951068
P21
P31
P496
0000-0002-0108-2402
P569
1949-01-01T00:00:00Z