From TIBO to Rilpivirine: The Chronicle of the Discovery of the Ideal Nonnucleoside Reverse Transcriptase Inhibitor

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Ten paths to the discovery of antivirally active nucleoside and nucleotide analogues.

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From TIBO to Rilpivirine: The Chronicle of the Discovery of the Ideal Nonnucleoside Reverse Transcriptase Inhibitor

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наукова стаття, опублікована в травні 2011

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From TIBO to Rilpivirine: The ...... everse Transcriptase Inhibitor

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From TIBO to Rilpivirine: The ...... everse Transcriptase Inhibitor

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From TIBO to Rilpivirine: The ...... everse Transcriptase Inhibitor

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From TIBO to Rilpivirine: The ...... everse Transcriptase Inhibitor

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From TIBO to Rilpivirine: The ...... everse Transcriptase Inhibitor

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From TIBO to Rilpivirine: The ...... everse Transcriptase Inhibitor

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From TIBO to Rilpivirine: The ...... everse Transcriptase Inhibitor

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Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations.

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design

Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives

Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TIBO) derivatives

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.

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377-389

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scholarly article

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10.1002/9783527635955.CH15

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Erik De Clercq

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2011-05-12T00:00:00Z

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