about
Drug discovery targeting amino acid racemases.Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria.Evading Pgp activity in drug-resistant cancer cells: a structural and functional study of antitubulin furan metotica compounds.Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic ActivityMechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue (+)-HIP-BSynthesis and in vitro/in vivo evaluation of the antitrypanosomal activity of 3-bromoacivicin, a potent CTP synthetase inhibitor.Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation.Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors.Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents.Development of novel selective peptidomimetics containing a boronic acid moiety, targeting the 20S proteasome as anticancer agents.Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptaSynthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of CaptoprilSynthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis.Synthesis and biochemical evaluation of δ(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors.Synthesis of 3-aryl/benzyl-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole derivatives: a comparison between conventional, microwave-assisted and flow-based methodologies.Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: design, synthesis, and pharmacological characterization.Design and synthesis of novel isoxazole-based HDAC inhibitors.The synthesis of azadirachtin: a potent insect antifeedant.Development of rhodesain inhibitors with a 3-bromoisoxazoline warhead.Synthesis of novel pyrrolo[3,4-d]pyrazole-dicarboxylic acids and evaluation of their interaction with glutamate receptors.Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.A stereospecific carboxyl esterase from Bacillus coagulans hosting nonlipase activity within a lipase-like fold.3-Carboxy-pyrazolinalanine as a new scaffold for developing potent and selective NMDA receptor antagonists.Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors.Selectivity of 3-bromo-isoxazoline inhibitors between human and Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenases.Inspired by Nature: The 3-Halo-4,5-dihydroisoxazole Moiety as a Novel Molecular Warhead for the Design of Covalent Inhibitors.Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain.Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.Synthesis and pharmacological evaluation of conformationally constrained glutamic acid higher homologues.Synthesis of natural products from the Indian neem tree Azadirachta indica.Flow-based biocatalysis: Application to peracetylated arabinofuranosyl-1,5-arabinofuranose synthesisFolates in Trypanosoma brucei: achievements and opportunitiesTetrahydro-4 H-(pyrrolo[3,4- d]isoxazol-3-yl)methanamine: A Bicyclic Diamino Scaffold Stabilizing Parallel Turn ConformationsOne-pot chemoenzymatic synthesis of aldoximes from primary alcohols in waterRationalizing the Lacking of Inversion Symmetry in a Noncentrosymmetric Polar Racemate: An Experimental and Theoretical StudySynthesis of a leopolic acid-inspired tetramic acid with antimicrobial activity against multidrug-resistant bacteriaUse of an o-Benzyl-(S)-Serine Containing Eluent for the Efficient Ligand-Exchange Chromatography-Based Enantioseparation of Constrained Glutamate Receptor LigandsEffects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Andrea Pinto
@ast
Andrea Pinto
@en
Andrea Pinto
@es
Andrea Pinto
@nl
type
label
Andrea Pinto
@ast
Andrea Pinto
@en
Andrea Pinto
@es
Andrea Pinto
@nl
prefLabel
Andrea Pinto
@ast
Andrea Pinto
@en
Andrea Pinto
@es
Andrea Pinto
@nl
P106
P1153
8931693400
P21
P31
P496
0000-0002-2501-3348