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A Molecular Mechanism for Bacterial Susceptibility to ZincImperfect coordination chemistry facilitates metal ion release in the Psa permeaseZnuA and zinc homeostasis in Pseudomonas aeruginosaDysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniaeImproving the stability and function of purified ABCB1 and ABCA4: the influence of membrane lipids.The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter.Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae.Molecular analysis of dimethyl sulphide dehydrogenase from Rhodovulum sulfidophilum: its place in the dimethyl sulphoxide reductase family of microbial molybdopterin-containing enzymes.Overlapping functionality of the Pht proteins in zinc homeostasis of Streptococcus pneumoniae.Acquisition and role of molybdate in Pseudomonas aeruginosa.Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae.Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach.Host-imposed manganese starvation of invading pathogens: two routes to the same destination.Degrees of chloroquine resistance in Plasmodium - is the redox system involved?Zinc stress induces copper depletion in Acinetobacter baumannii.The First Histidine Triad Motif of PhtD Is Critical for Zinc Homeostasis in Streptococcus pneumoniae.How can we best use structural information on P-glycoprotein to design inhibitors?The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis.Prokaryotic substrate-binding proteins as targets for antimicrobial therapies.Manganese uptake and streptococcal virulence.Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy.Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence.Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA.The zinc efflux activator SczA protects Streptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity.Microstructured Optical Fiber-based Biosensors: Reversible and Nanoliter-Scale Measurement of Zinc Ions.Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography.Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.Genome-wide mutagenesis of dengue virus reveals plasticity of the NS1 protein and enables generation of infectious tagged reporter viruses.AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae.Microstructured optical fibers and live cells: a water-soluble, photochromic zinc sensor.The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity.Biotin-mediated growth and gene expression in Staphylococcus aureus is highly responsive to environmental biotin.Subunit composition and in vivo substrate-binding characteristics of Escherichia coli Tat protein complexes expressed at native levels.Characterisation of Tat protein transport complexes carrying inactivating mutations.Arachidonic Acid Stress Impacts Pneumococcal Fatty Acid Homeostasis.Synergy between nutritional immunity and independent host defenses contributes to the importance of the MntABC manganese transporter during infectionChemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic ResistanceA Liposomal Platform for Sensing of Extracellular Analytes Near CellsIdentification of Novel Host Fatty Acid Stress Adaptation Strategies
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Christopher A McDevitt
@ast
Christopher A McDevitt
@en
Christopher A McDevitt
@es
Christopher A McDevitt
@nl
type
label
Christopher A McDevitt
@ast
Christopher A McDevitt
@en
Christopher A McDevitt
@es
Christopher A McDevitt
@nl
prefLabel
Christopher A McDevitt
@ast
Christopher A McDevitt
@en
Christopher A McDevitt
@es
Christopher A McDevitt
@nl
P106
P21
P31
P496
0000-0003-1596-4841