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Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady-state retention of mutant forms in the proximal golgiMahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with GalphasThe 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinaseMolecular basis of the extreme dilution mottled mouse mutation: a combination of coding and noncoding genomic alterationsRegulation of mammalian melanogenesis. I: Partial purification and characterization of a dopachrome converting factor: dopachrome tautomeraseMolecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanomaMelanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studiesMelanocortin-1 receptor structure and functional regulation.Molecular anatomy of tyrosinase and its related proteins: beyond the histidine-bound metal catalytic center.Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT.MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project.Functional Characterization of MC1R-TUBB3 Intergenic Splice Variants of the Human Melanocortin 1 Receptor.Identification and functional characterization of natural human melanocortin 1 receptor mutant alleles in Pakistani population.Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology.Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawalMC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentationThe dioxin receptor has tumor suppressor activity in melanoma growth and metastasis.Association of Melanocortin-1 Receptor Variants with Pigmentary Traits in Humans: A Pooled Analysis from the M-Skip Project.MC1R signaling. Intracellular partners and pathophysiological implications.Functional status and relationships of melanocortin 1 receptor signaling to the cAMP and extracellular signal-regulated protein kinases 1 and 2 pathways in human melanoma cells.Functional interplay between secreted ligands and receptors in melanoma.Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients.Regulation of human melanocortin 1 receptor signaling and trafficking by Thr-308 and Ser-316 and its alteration in variant alleles associated with red hair and skin cancer.Agonist-independent, high constitutive activity of the human melanocortin 1 receptor.Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function.Thr40 and Met122 are new partial loss-of-function natural mutations of the human melanocortin 1 receptor.Sticky fingers at work: palmitoylation-dependent MC1R activation.Identification of active site residues involved in metal cofactor binding and stereospecific substrate recognition in Mammalian tyrosinase. Implications to the catalytic cycle.Regulation of tyrosine hydroxylase levels and activity and Fos expression during opioid withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups innervating the PVN.Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase.The mouse silver locus encodes a single transcript truncated by the silver mutation.alpha-Melanotropin immunoreactivity in human melanoma exudate is related to necrosis.N-glycosylation of the human melanocortin 1 receptor: occupancy of glycosylation sequons and functional role.Apoptosis and molecular pathways in the seminiferous epithelium of aged and photoinhibited Syrian hamsters (Mesocricetus auratus).MC1R variants as melanoma risk factors independent of at-risk phenotypic characteristics: a pooled analysis from the M-SKIP project.Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human TyrosinaseComparative action of dopachrome tautomerase and metal ions on the rearrangement of dopachromecAMP-independent non-pigmentary actions of variant melanocortin 1 receptor: AKT-mediated activation of protective responses to oxidative DNA damageAlpha-MSH and other melanogenic activators mediate opposite effects on tyrosinase and dopachrome tautomerase in B16/F10 mouse melanoma cellsMelanocyte stimulating hormone activation of tyrosinase in B16 mouse melanoma cells. Evidence for a differential induction of two distinct isoenzymes
P50
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P50
description
researcher
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researcher
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հետազոտող
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name
José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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José C García-Borrón
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P106
P21
P31
P496
0000-0002-9192-588X