about
Mitochondrial glutathione: features, regulation and role in diseaseCholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidityDefective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice.CYP2E1-dependent toxicity and up-regulation of antioxidant genes.Induction of catalase, alpha, and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress.Mitochondrial glutathione, a key survival antioxidant.Redox control of liver function in health and diseaseCholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell deathAcidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesisGrowth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury.Angiogenin secretion from hepatoma cells activates hepatic stellate cells to amplify a self-sustained cycle promoting liver cancer.Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.Glycosphingolipids and mitochondria: role in apoptosis and disease.Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation.Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitisCathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potentialReactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion.ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation.Alcohol, signaling, and ECM turnover.Metabolic therapy: lessons from liver diseases.Hepatocarcinogenesis and ceramide/cholesterol metabolism.Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: cause or consequence?Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress.Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis.Mitochondrial cholesterol: a connection between caveolin, metabolism, and disease.Ileal FGF15 contributes to fibrosis-associated hepatocellular carcinoma development.Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis.Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma.Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia.CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase.Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility.Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase.Sphingolipid signalling and liver diseases.Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans.Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1.Mitochondrial permeability transition induced by reactive oxygen species is independent of cholesterol-regulated membrane fluidity.Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation.Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury.Bone morphogenetic protein-9/activin-like kinase 1 axis a new target for hepatic regeneration and fibrosis treatment in liver injury.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Montserrat Marí
@ast
Montserrat Marí
@en
Montserrat Marí
@es
Montserrat Marí
@nl
type
label
Montserrat Marí
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Montserrat Marí
@en
Montserrat Marí
@es
Montserrat Marí
@nl
prefLabel
Montserrat Marí
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Montserrat Marí
@en
Montserrat Marí
@es
Montserrat Marí
@nl
P106
P1153
7005923174
P21
P31
P496
0000-0002-6116-3247