Recombinant apoptin multimers kill tumor cells but are nontoxic and epitope-shielded in a normal-cell-specific fashion

Recombinant apoptin multimers kill tumor cells but are nontoxic and epitope-shielded in a normal-cell-specific fashion

Item
http://www.wikidata.org/entity/Q56875733
Generic cell dysfunction in neurodegenerative disorders: role of surfaces in early protein misfolding, aggregation, and aggregate cytotoxicity.Novel characteristics of the avian gyrovirus 2 genome.Inhibition of aggregate formation as therapeutic target in protein misfolding diseases: effect of tetracycline and trehalose.Viral genes as oncolytic agents for cancer therapy.Selective apoptosis induction in MCF-7 cell line by truncated minimal functional region of Apoptin.Apoptin selectively induces the apoptosis of tumor cells by suppressing the transcription of HSP70.Molecularly modified VP3 (30-121) induces apoptosis in human bladder cancer (EJ) cells but not in normal (3T3) cells.Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin.Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and ΔNp73 isoforms through ubiquitin ligase PIR2.Additive cytotoxic effect of apoptin and chemotherapeutic agents paclitaxel and etoposide on human tumour cells.Inhibition of hepatocarcinoma by systemic delivery of Apoptin gene via the hepatic asialoglycoprotein receptor.The yeast prion Ure2p native-like assemblies are toxic to mammalian cells regardless of their aggregation state.A truncated apoptin protein variant selectively kills cancer cells.Apoptin's functional N- and C-termini independently bind DNA
P2860

Recombinant apoptin multimers kill tumor cells but are nontoxic and epitope-shielded in a normal-cell-specific fashion

Item
http://www.wikidata.org/entity/Q56875733
description
im September 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 September 2003
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 2003
@uk
name
Recombinant apoptin multimers ...... a normal-cell-specific fashion
@en
Recombinant apoptin multimers ...... a normal-cell-specific fashion
@nl
type
label
Recombinant apoptin multimers ...... a normal-cell-specific fashion
@en
Recombinant apoptin multimers ...... a normal-cell-specific fashion
@nl
prefLabel
Recombinant apoptin multimers ...... a normal-cell-specific fashion
@en
Recombinant apoptin multimers ...... a normal-cell-specific fashion
@nl
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Recombinant Apoptin multimers ...... a normal-cell-specific fashion
@en
P2093
P304
P31
P356
10.1016/S0014-4827(03)00188-5
P407
P433
P478
P50
P577
P698