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Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of ViridiplantaeEfflux-mediated drug resistance in bacteria: an updateAn undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coliAnalyzing conformational changes in the transport cycle of EmrEX-ray structure of EmrE supports dual topology model.Structural basis for amino acid export by DMT superfamily transporter YddGProtonation of a glutamate residue modulates the dynamics of the drug transporter EmrELipid-dependent generation of dual topology for a membrane protein.Lipid bilayer composition influences small multidrug transporters.Diversity and evolution of the small multidrug resistance protein family.Molecular evolution of a novel family of putative calcium transporters.Topologically random insertion of EmrE supports a pathway for evolution of inverted repeats in ion-coupled transportersStructure, dynamics, and substrate-induced conformational changes of the multidrug transporter EmrE in liposomes.Antiparallel EmrE exports drugs by exchanging between asymmetric structuresControl of membrane protein topology by a single C-terminal residue.A model-structure of a periplasm-facing state of the NhaA antiporter suggests the molecular underpinnings of pH-induced conformational changes.Antiparallel dimers of the small multidrug resistance protein EmrE are more stable than parallel dimers.Internal duplications in α-helical membrane protein topologies are common but the nonduplicated forms are rare.The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.Membrane localization of small proteins in Escherichia coli.Undecided membrane proteins insert in random topologies. Up, down and sideways: it does not really matterDetermining the N-terminal orientations of recombinant transmembrane proteins in the Escherichia coli plasma membrane.Regulation of multispanning membrane protein topology via post-translational annealing.Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimersParallel topology of genetically fused EmrE homodimers.Mechanism for alternating access in neurotransmitter transporters.An emerging consensus for the structure of EmrE.Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening.Knowledge-based computational intelligence development for predicting protein secondary structures from sequences.NMR and EPR studies of membrane transporters.Synthetic biology: understanding biological design from synthetic circuits.Structural perspectives on secondary active transporters.Life at the border: adaptation of proteins to anisotropic membrane environment.Identification of a glycine motif required for packing in EmrE, a multidrug transporter from Escherichia coli.Dual-topology insertion of a dual-topology membrane protein.Electron crystallography reveals plasticity within the drug binding site of the small multidrug transporter EmrE.The messy process of guiding proteins into membranes.1H, 13C, 15N backbone NMR assignments of the Staphylococcus aureus small multidrug-resistance pump (Smr) in a functionally active conformation.Ligand-induced conformational changes of the multidrug resistance transporter EmrE probed by oriented solid-state NMR spectroscopy.The free and bound forms of Lpp occupy distinct subcellular locations in Escherichia coli.
P2860
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P2860
description
article publié dans la revue scientifique Science
@fr
im März 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Science
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в березні 2007
@uk
name
Emulating membrane protein evolution by rational design
@en
Emulating membrane protein evolution by rational design
@nl
type
label
Emulating membrane protein evolution by rational design
@en
Emulating membrane protein evolution by rational design
@nl
altLabel
Emulating Membrane Protein Evolution by Rational Design
@en
Emulating Membrane Protein Evolution by Rational Design
@nl
prefLabel
Emulating membrane protein evolution by rational design
@en
Emulating membrane protein evolution by rational design
@nl
P2093
P2860
P50
P356
P1433
P1476
Emulating Membrane Protein Evolution by Rational Design
@en
Emulating membrane protein evolution by rational design
@en
P2093
E. Granseth
Erik Granseth
S. Seppala
P2860
P356
10.1126/SCIENCE.1135406
P407
P577
2007-01-25T00:00:00Z
2007-03-02T00:00:00Z