Structural basis for broad DNA-specificity in integron recombination
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Effect of attC structure on cassette excision by integron integrasesUnmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovationAn Interlocked Dimer of the Protelomerase TelK Distorts DNA Structure for the Formation of Hairpin TelomeresArchitecture of a Serine Recombinase-DNA Regulatory ComplexThe Carboxy-Terminal αN Helix of the Archaeal XerA Tyrosine Recombinase Is a Molecular Switch to Control Site-Specific RecombinationThe Structure of an Archaeal Viral Integrase Reveals an Evolutionarily Conserved Catalytic Core yet Supports a Mechanism of DNA Cleavage in transA new in vitro strand transfer assay for monitoring bacterial class 1 integron recombinase IntI1 activityInverse correlation between promoter strength and excision activity in class 1 integronsA recalibrated molecular clock and independent origins for the cholera pandemic clonesPrevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons.Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen.Worldwide prevalence of class 2 integrases outside the clinical setting is associated with human impactIn vitro recombination catalyzed by bacterial class 1 integron integrase IntI1 involves cooperative binding and specific oligomeric intermediatesIdentification of key structural determinants of the IntI1 integron integrase that influence attC x attI1 recombination efficiency.Insights and inferences about integron evolution from genomic data.First gene cassettes of integrons as targets in finding adaptive genes in metagenomes.ACID: annotation of cassette and integron dataStructural features of single-stranded integron cassette attC sites and their role in strand selection.Structure-function analysis of IntDOT.The relaxed requirements of the integron cleavage site allow predictable changes in integron target specificity.Characterization of the novel In1059 harbouring VIM gene cassette.Molecular keys of the tropism of integration of the cholera toxin phage.Integrons: past, present, and future.Characterization of Novel Integrons, In1085 and In1086, and the Surrounding Genes in Plasmids from Enterobacteriaceae, and the Role for attCaadA16 Structural Features during attI1 × attC Integration.Control of directionality in the DNA strand-exchange reaction catalysed by the tyrosine recombinase TnpI.Cellular pathways controlling integron cassette site folding.A group IIC-type intron interrupts the rRNA methylase gene of Geobacillus stearothermophilus strain 10.Folded DNA in action: hairpin formation and biological functions in prokaryotes.Holliday junction affinity of the base excision repair factor Endo III contributes to cholera toxin phage integration.Initial characterization of the Pf-Int recombinase from the malaria parasite Plasmodium falciparumIntegrase-mediated recombination of the veb1 gene cassette encoding an extended-spectrum β-lactamase.A molecular dynamics study of slow base flipping in DNA using conformational floodingLocal mobile gene pools rapidly cross species boundaries to create endemicity within global Vibrio cholerae populations.Marine integrons containing novel integrase genes, attachment sites, attI, and associated gene cassettes in polluted sediments from Suez and Tokyo Bays.Dynamic mechanisms for pre-miRNA binding and export by Exportin-5.Diversity of Class 1 Integron Gene Cassette Rearrangements Selected under Antibiotic Pressure.Insertion of group II intron retroelements after intrinsic transcriptional terminatorsReplicative resolution of integron cassette insertionA family of insertion sequences that impacts integrons by specific targeting of gene cassette recombination sites, the IS1111-attC GroupFunctional characterization of Tn1331 gene cassettes.
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Structural basis for broad DNA-specificity in integron recombination
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
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wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature у квітні 2006
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name
Structural basis for broad DNA-specificity in integron recombination
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Structural basis for broad DNA-specificity in integron recombination
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type
label
Structural basis for broad DNA-specificity in integron recombination
@en
Structural basis for broad DNA-specificity in integron recombination
@nl
prefLabel
Structural basis for broad DNA-specificity in integron recombination
@en
Structural basis for broad DNA-specificity in integron recombination
@nl
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P356
P1433
P1476
Structural basis for broad DNA-specificity in integron recombination
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Douglas MacDonald
Gaëlle Demarre
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P2888
P304
P356
10.1038/NATURE04643
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P577
2006-04-27T00:00:00Z
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1033786250