about
Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesisConversion of a disulfide bond into a thioacetal group during echinomycin biosynthesisEpoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesisBiochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide BiosynthesisCloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha.Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus.Diversification of echinomycin molecular structure by way of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway.Plasmid construction using recombination activity in the fission yeast Schizosaccharomyces pombe.Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.Methylation-dependent acyl transfer between polyketide synthase and nonribosomal peptide synthetase modules in fungal natural product biosynthesis.Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.A polyketide macrolactone synthase from the filamentous fungus Gibberella zeaeRobust platform for de novo production of heterologous polyketides and nonribosomal peptides in Escherichia coli.Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway.A comprehensive and engaging overview of the type III family of polyketide synthases.Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition.Exploring the biosynthesis of natural products and their inherent suitability for the rational design of desirable compounds through genetic engineering.Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases.Pictet-Spenglerase involved in tetrahydroisoquinoline antibiotic biosynthesis.Robustness analysis of cellular systems using the genetic tug-of-war method.Biosynthetic machinery of ionophore polyether lasalocid: enzymatic construction of polyether skeleton.Yeast-based genome mining, production and mechanistic studies of the biosynthesis of fungal polyketide and peptide natural products.Oxidative Cyclization in Natural Product BiosynthesisNew natural products isolated from Metarhizium robertsii ARSEF 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in Aspergillus nidulans A1145.Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme.Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis.Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids.Biochemical Characterization of a Eukaryotic Decalin-Forming Diels-AlderaseEnzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis.Redirecting the cyclization steps of fungal polyketide synthase.Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids.Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis.Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics.Targeted disruption of transcriptional regulators in Chaetomium globosum activates biosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol.Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.Synergistic actions of a monooxygenase and cyclases in aromatic polyketide biosynthesis.
P50
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P50
description
onderzoeker
@nl
researcher ORCID: 0000-0002-0463-4831
@en
name
Kenji Watanabe
@ast
Kenji Watanabe
@en
Kenji Watanabe
@es
Kenji Watanabe
@nl
type
label
Kenji Watanabe
@ast
Kenji Watanabe
@en
Kenji Watanabe
@es
Kenji Watanabe
@nl
prefLabel
Kenji Watanabe
@ast
Kenji Watanabe
@en
Kenji Watanabe
@es
Kenji Watanabe
@nl
P106
P31
P496
0000-0002-0463-4831