Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

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Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

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im August 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 19 June 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в серпні 2018

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name

Cilia-localized LKB1 regulates ...... ssue homeostasis in the kidney

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Cilia-localized LKB1 regulates ...... ssue homeostasis in the kidney

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Cilia-localized LKB1 regulates ...... ssue homeostasis in the kidney

@en

Cilia-localized LKB1 regulates ...... ssue homeostasis in the kidney

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Cilia-localized LKB1 regulates ...... ssue homeostasis in the kidney

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Cilia-localized LKB1 regulates ...... ssue homeostasis in the kidney

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Cilia-localized LKB1 regulates ...... ssue homeostasis in the kidney

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Abhijeet P Todkar

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Amandine Viau

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Annette Merkle

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Antigoni Triantafyllopoulou

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Dietmar Pfeifer

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Fabiola Terzi

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Florian Grahammer

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Frank Bienaimé

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Gerd Walz

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Kamile Lukas

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P2860

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis

The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

VEGF inhibition and renal thrombotic microangiopathy

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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e98615

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scholarly article

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10.15252/EMBJ.201798615

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English

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P478

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2018-06-19T00:00:00Z

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29925518

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P921

macrophage

molecular biology

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6068446

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