about
Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicityGenetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile.Non-linear dose-response of DNA-reactive genotoxins: recommendations for data analysis.Genetic and Epigenetic Intra-tumour Heterogeneity in Colorectal CancerExtramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: Influence of the CpG island methylator phenotype.Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells.The polymerase inhibition assay: A methodology for the identification of DNA-damaging agents.Do dose response thresholds exist for genotoxic alkylating agents?Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus.Expression of bile acid transporting proteins in Barrett's esophagus and esophageal adenocarcinoma.Review of the development of DNA methylation as a marker of response to neoadjuvant therapy and outcomes in rectal cancer.Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasiaCharacterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma.Early p53 mutations in nondysplastic Barrett's tissue detected by the restriction site mutation (RSM) methodology.NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials.Genotoxic thresholds, DNA repair, and susceptibility in human populations.Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses.The role of secondary bile acids in neoplastic development in the oesophagus.The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.Enhanced restriction site mutation (RSM) analysis of 1,2-dimethylhydrazine induced mutations, using endogenous p53 intron sequences.Diagnostic correlation between the expression of the DNA repair enzyme N-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study.Analysis of the premalignant stages of Barrett's oesophagus through to adenocarcinoma by comparative genomic hybridization.Investigation of J-shaped dose-responses induced by exposure to the alkylating agent N-methyl-N-nitrosourea.A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity.Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistriesCell type-dependent changes in CdSe/ZnS quantum dot uptake and toxic endpoints.Acute dosing and p53-deficiency promote cellular sensitivity to DNA methylating agents.Genotoxins induce binucleation in L5178Y and TK6 cells.Is Nickel Chloride really a Non-Genotoxic Carcinogen?Reflux composition influences the level of NF-κB activation and upstream kinase preference in oesophageal adenocarcinoma cells.Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells.Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent.Curcumin abrogates bile-induced NF-κB activity and DNA damage in vitro and suppresses NF-κB activity whilst promoting apoptosis in vivo, suggesting chemopreventative potential in Barrett's oesophagus.Single-walled carbon nanotubes: differential genotoxic potential associated with physico-chemical properties.The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles.In vitro and ex vivo models of extended reflux exposure demonstrate that weakly acidic mixed reflux heightens NF-kB-mediated gene expression.N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage.The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-kappaB activation in oesophageal cells, with a mechanism of action involving ROS.
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Gareth J Jenkins
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Gareth J Jenkins
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Gareth J Jenkins
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Gareth J Jenkins
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type
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Gareth J Jenkins
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Gareth J Jenkins
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Gareth J Jenkins
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Gareth J Jenkins
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prefLabel
Gareth J Jenkins
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Gareth J Jenkins
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Gareth J Jenkins
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Gareth J Jenkins
@nl
P106
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16309264200
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P31
P496
0000-0002-5437-8389