about
Axial chirality control during Suzuki-Miyaura cross-coupling reactions: the tert-butylsulfinyl group as an efficient chiral auxiliary.Atropisomerism, biphenyls, and fluorine: a comparison of rotational barriers and twist angles.Alpha-fluorinated ethers, thioethers, and amines: anomerically biased species.Inhibition of p450 17 as a new strategy for the treatment of prostate cancer.alpha-fluorinated ethers as "exotic" entity in medicinal chemistry.Recent advances in transition metal-catalyzed Csp(2)-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation.Trifluoromethyl ethers and -thioethers as tools for medicinal chemistry and drug discovery.Recent advances and new concepts for the synthesis of axially stereoenriched biaryls.Bromine-lithium exchange: An efficient tool in the modular construction of biaryl ligands.Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents.Trifluoromethoxy substituted anilines: metalation as the key step for structural elaboration.A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation.Asymmetric α-Sulfonyl- and α-Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III).A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns.Synthesis of Mono- and Bis(fluoroalkyl)pyrimidines from FARs, Fluorinated Acetoacetates, and Malononitrile Provides Easy Access to Novel High-Value Pyrimidine Scaffolds.Switchable Diastereoselectivity in the Fluoride-Promoted Vinylogous Mukaiyama-Michael Reaction of 2-[(Trimethylsilyl)oxy]furan Catalyzed by Crown Ethers.Multiple hydrogen/lithium interconversions at the same benzene nucleus: two at the most.Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.Stereoselectivity Switch in the Trapping of Polar Organometallics with Andersen’s Reagent—Access to Highly Stereoenriched Transformable BiphenylsAccess towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliariesFluoroalkyl Amino Reagents for the Introduction of the Fluoro(trifluoromethoxy)methyl Group onto Arenes and HeterocyclesDetermination of the absolute configuration of phosphinic analogues of glutamateIn Situ Generated Fluorinated Iminium Salts for Difluoromethylation and DifluoroacetylationPalladium-Catalyzed Intramolecular Direct Arylation of 2-Bromo-diaryl Sulfoxides via C–H Bond ActivationConstruction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki–Miyaura couplingStereoselective Synthesis of P-Chirogenic Dibenzophosphole–Boranes via Aryne IntermediatesStereoselective Synthesis of o-Bromo (or Iodo)aryl P-Chirogenic Phosphines Based on Aryne Chemistry[1,2,3]Triazolo[1,5-a]pyridyl phosphines reflecting the influence of phosphorus lone pair orientation on spectroscopic propertiesHighly Efficient One-Pot Access to Functionalized Arylboronic Acids via Noncryogenic Bromine/Magnesium ExchangesEfficient Synthesis of Quaternary and P-Stereogenic Phosphonium Triflates†Palladium-Catalyzed Borylation of Phenyl Bromides and Application in One-Pot Suzuki−Miyaura Biphenyl SynthesisThe "Aryne" route to biaryls featuring uncommon substituent patterns
P50
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P50
description
researcher
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ricercatore
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wetenschapper
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հետազոտող
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name
Frédéric R Leroux
@ast
Frédéric R Leroux
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Frédéric R Leroux
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Frédéric R Leroux
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type
label
Frédéric R Leroux
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Frédéric R Leroux
@en
Frédéric R Leroux
@es
Frédéric R Leroux
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prefLabel
Frédéric R Leroux
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Frédéric R Leroux
@en
Frédéric R Leroux
@es
Frédéric R Leroux
@nl
P214
P106
P21
P214
P31
P496
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P735
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viaf-202289401