about
Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexesTemperature dependence of cross-effect dynamic nuclear polarization in rotating solids: advantages of elevated temperatures.Tractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform.Selective non-lipid modulator of LPA5 activity in human platelets.Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 InhibitorsModulation of Hexadecyl-LPA-Mediated Activation of Mast Cells and Microglia by a Chemical Probe for LPA5.5-Aryl-2-(naphtha-1-yl)sulfonamido-thiazol-4(5H)-ones as clathrin inhibitors.Loss of Ptpn11 (Shp2) drives satellite cells into quiescenceIdentification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone.Enantiospecific synthesis of the (9S,18R)-diastereomer of the leukocyte adhesion inhibitor cyclamenol A.Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents.A flexible, palladium-catalyzed indole and azaindole synthesis by direct annulation of chloroanilines and chloroaminopyridines with ketones.Evidence for C-Cl/C-Br...pi interactions as an important contribution to protein-ligand binding affinity.Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.Identification and Characterization of a Single High-Affinity Fatty Acid Binding Site in Human Serum Albumin.Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.Organophosphorus-mediated N-N bond formation: facile access to 3-amino-2H-indazoles.N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist.A General One-Pot Synthesis of 2H-Indazoles Using an Organophosphorus-Silane System.Direct Experimental Evidence for Halogen-Aryl π Interactions in Solution from Molecular Torsion Balances.Chemical fragment arrays for rapid druggability assessment.DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis.Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging.Synthesis of the (9S,18R)-seco acid of the leukocyte adhesion inhibitor cyclamenol AEfficient enantioselective synthesis of a β-hydroxyepoxide building block for the construction of macrocyclic natural productsAllosteric inhibition of a mammalian lectinA new highly thyrotropin receptor-selective small molecule antagonist with potential for the treatment of Graves' orbitopathyvisualization of osteoarthritic hypertrophic lesionsUse of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathwayEU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical BiologySynthesis of the (9S,18R) Diastereomer of Cyclamenol A This research was supported by the Bayer AG and the Fonds der chemischen IndustrieA general and mild domino approach to substituted 1-aminoindolesA general and mild palladium-catalyzed domino reaction for the synthesis of 2H-indazolesIdentification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer CellsProbing 2H-Indazoles as Templates for SGK1, Tie2, and SRC Kinase InhibitorsA pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channelsRevealing cytotoxic substructures in molecules using deep learningSmall-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia CellsRapid Synthesis of γ-Halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Marc Nazaré
@ast
Marc Nazaré
@en
Marc Nazaré
@es
Marc Nazaré
@nl
type
label
Marc Nazaré
@ast
Marc Nazaré
@en
Marc Nazaré
@es
Marc Nazaré
@nl
prefLabel
Marc Nazaré
@ast
Marc Nazaré
@en
Marc Nazaré
@es
Marc Nazaré
@nl
P106
P21
P31
P496
0000-0002-1602-2330